垂体泌乳素瘤早期诊断的临床研究

Clinical study of early diagnosis of prolactionma

目的:探讨血清泌乳素(PRL)的测定及核磁共振(MR I)检查对早期诊断垂体泌乳素瘤的作用。方法:选择主诉有闭经、泌乳、月经频发、月经稀少、不孕、性功能减退、头痛、肥胖等症状并排除服药、妊娠、哺乳、应激、下丘脑疾病等其他情况的女性,进行血清PRL检测。血清PRL>50μg/L的患者随机抽出55例为阳性组,血清PRL<50μg/L的患者随机抽出60例为阴性组,进行核磁共振检查。两组妇女以后1次/3个月进行血清PRL、核磁共振检查,跟踪24个月。结果:血清PRL>50μg/L的阳性组发现有8例垂体泌乳素瘤,血清PRL<50μg/L的阴性组发现1例垂体泌乳素瘤。血清PRL的水平对临床表现有影响。结论:血清PRL的测定及核磁共振检查对诊断垂体泌乳素瘤有重要意义,对于血清PRL>50μg/L的患者1次/3个月进行血清PRL检测、核磁共振检查对早期诊断垂体泌乳素瘤的作用有待进一步观察。

Objective： To explore the effects of detecting serum PRL combined with MRI examination on early diagnosis of prolactionma. Methods： Serum PRL assessment in women with chief complaints of amenorrhea, lactorrhea, polymenorrhea, oligomenorrhea, infertility, and impairment of sexual function with symptoms of headache and obesity was carried out. 55 patients with higher serum PRL level than 50μg/L were randomly selected to be the positive group, while other 60 patients randomly selected from all patients with a lower than 50μg/L were in the negative group. MRI examination was performed. Serum PRL assessment and MRI examinations were carried out to these two groups of patients once every three months and were followed up for 24 months. Results： 8 cases prolactionma were discovered in the positive group, while among negative group only 1 cases of such tumors was found. Serum PRL level had influence on clinical manifestations. Conclusion： Serum PRL assessment accompanied by MRI examinations possesses crucial important significance in the diagnosis of prolactinoma. The action of serum PRL assessment once every three months accompanied by PRL examinations on cases with their serum PRL level above 50μg/L for an early clinical diagnosis of orolactinoma needs to be further exolored and observed.