胰岛素泵短期强化治疗2型糖尿病的临床研究

Clinical study on intensive insulin treatment for type 2 diabetes with continuous insulin pump

目的研究胰岛素泵连续输注给药在2型糖尿病强化治疗中的应用效果.方法共76例患者接受胰岛素泵连续输注给药的治疗.血糖控制平稳后,5例改为口服药治疗,68例改为分次胰岛素皮下注射,3例危重患者因自动出院中断治疗.结果带泵治疗3～12 d,平均为(6.2±2.0)d,均能使血糖获得良好控制.胰岛素基础量、追加量之比接近2:3,三餐前追加量接近各1/3.低血糖反应发生率为每例0.06次/d.结论采用胰岛素泵连续输注给药的方式较符合生理状况,血糖控制佳,低血糖发生率低,为糖尿病强化治疗提供了一种安全、有效、方便的新方法.

Objective To investigate the effect of continuous subcutaneous insulin infusion（CSII） for intensive insulin treatment. Methods 76 patients were studied by CSII method. After under controlled of hyperglycemia, under 5 patients were switched to oral hypoglycemic agent and 68 patients were turned to splitting subcutaneous insulin injection（MSID. Results After CSII for 3 to 12 days, an average 6.2±2.0 days, the hyperglycemia could be controlled effectively. The ratio of basal dose to bolus of insulin was in access to 2 ： 3. The ratio of boluses before three meals was 1 ： 1 ： 1. The frequency of hypoglycemia in CSII of each case was 0.06 time/d. Conclusions Since CSII mimicks the physiological insulin secretion, hyperglycemia can be controlled more effectively, with less hypoglycemia episode, which provides a safe, effective and convenient new method for intensive insulin treatment. （ Shanghai Med J, 2005,28 ： 768-769）