巨噬细胞泡沫化抑制剂的研究进展

Research development of inhibitors for macrophage foam cell formation

胆固醇酯蓄积的巨噬细胞(泡沫细胞)是早期动脉粥样硬化斑块的主要组成和特征。它通过其细胞表面的多种受体无限制地摄取氧化型低密度脂蛋白(ox-LDL)颗粒及其他配体,结果在巨噬细胞内有大量的胆固醇酯和三酰甘油蓄积,使巨噬细胞发展成为泡沫细胞。因此,通过各种途径抑制这种在巨噬细胞的过量脂质蓄积,可以起到预防和治疗动脉粥样硬化的作用。

The accumulation of cholesterol esters in macrophages （foam cells）is the main structural and characteristic atherosclerotic soft plaque formation of early atherosclerosis. Several receptors, which are expressed at the cell surface of macrophages, can mediate the uptake of oxidized low-density lipoprotein and other ligands, resulting in a large number of cholesterol esters and triglycerides with final development of foam cells. Thus, it serves as an effective method to prevent and treat atherosclerosis by inhibiting the process of lipid accumulation in macrophages