外源性胃电刺激对犬胃慢波的作用

Effect of exogenous gastric electrical stimulation on gastric slow waves in dogs

目的探讨外源性胃电刺激完全控制胃慢波的最佳刺激方法和最佳刺激参数。方法在8条比格犬的胃大弯浆膜层埋植4对电极,分4组:单导联刺激组、两导联刺激组、三导联刺激组和三导联延迟刺激组。多导联电刺激器与距胃窦上6、10和14cm的浆膜电极相连并输入不同宽度和振幅的脉冲以控制胃慢波。运用多导联胃电记录仪记录胃肌电活动。观察实验中胃慢波、脉冲宽度和振幅。结果长脉冲胃电刺激能控制胃慢波。单导联刺激组所需的最佳刺激能量最小(51.25±12.46,P<0.01)。三导联刺激组较其延迟刺激组所需的最佳刺激能量值低(P<0.01)。刺激前后胃肌电活动的主功和胃慢波的传播速度差异无统计学意义(P>0.05)。结论长脉冲胃电刺激能控制胃慢波,但对胃肌电活动的主功和传播速度无作用。单导联胃电刺激控制胃慢波所需的刺激能量最小。导联之间的延迟时间能增加控制胃慢波所需的最佳刺激能量。

Objective To identify the optimal method and parameters of exogenous gastric electrical stimulation （GES） for completely control of gastric slow waves （GSW）. Methods Eight beagle dogs were implanted with 4 pairs of electrodes into gastric serosa. All dogs were randomly divided into four groups： single-channel GES group, 2 channel GES group, 3 channel GES group and 3-channel delay GES group, A multi channel electrical stimulator with different pulse width and pulse amplitude was connected to the electrodes 6 cm. 10 cmand 14 cmabovethe pylorus in order to controlGSW. Gastricmyo- electrical activity including GSW, pulse width and pulse amplitude was recorded by using multi-channel recorder. Results 1.ong pulse GES was able to control GSW. The optimal energy required by single- channel GES group E（75.00± 15.08） ms × mA] was the lowest among all study groups （P〈0.01）. The optimal energy required by 3 channel （;ES group was significantly lower than that by 3-channel delay GESgroup （P〈0.01）. There was no significant difference in dominant power and propagation velocity of GSW before and after GES （P》0.05）. Conclusions Long pulses C-ES can control GSW but have no effect on dominant power and propagation velocity of gastric myoelectrical activity. Single-channel GES requires the lowest pacing energy to control GSW. Time delay between channels may increase the optimal energy to control GSW.