胰腺癌病理学及分子病理学的研究进展

Progression on pathology and molecular pathology of pancreatic carcinoma

胰腺癌发病率近年呈上升趋势,已位于我国肿瘤死因的第七位。胰腺癌临床经过凶险、预后差,近10余年患者的5年生存率亦无明显提高,外科手术切除仍是目前主要的治疗手段之一,尚缺乏有效的综合治疗方法。胰腺癌病理学和分子病理学研究主要集中于胰腺癌发病的分子机制、癌基因和抑癌基因、侵袭和转移等方面,同时寻找新的早期诊断和预后标记物,发现新的治疗靶点。本文对近年胰腺癌病理学和分子病理学研究进展作一简要回顾。

The incidence of pancreatic cancer is increasing and it ranks 7th in all cancer-related deaths in China. Pancreatic carcinoma is characterized by extremely poor prognosis and rapid progression, with no improvement in the 5-year survival rate over the last decade. Surgical resection remains a major treatment for patients with pancreatic cancer, but effective comprehensive treatments are still needed. Current researches of pancreatic cancer pathology mainly focus on the molecular mechanism of pancreatic cancer development, oncogenes and suppressor genes, and invasion and metastasis. It is also very important to search for new markers for early diagnosis and prognosis and to develop novel therapeutic targets. This paper presents the recent progression of pathology and molecular pathology of pancreatic carcinoma.