金叶子的化学成分

Chemical Constituents from Craibiodendron yunnanense

从金叶子(Craibiodendron yunnanense W.W.Smith)叶部分的70%丙酮提取液中共分离得15个化合物,分别鉴定为:asebotoxin-III (1),grayanotoxin-XVIII (2),leucothol A (3),proA-4 (4),槲皮素-3-O-β-半乳吡喃糖苷(5),槲皮素-3-O-α-阿拉伯呋喃糖苷(6),槲皮素-3-O-α-鼠李吡喃糖苷(7),山奈酚-3-O-α-鼠李吡喃糖苷(8),2,4-bis (4-hydroxyphengl)-1,3-cyclobutane dicarboxglic aicd (9),(Z)-对羟基桂皮酸(10),(E)-对羟基桂皮酸(11),香草酸(12),2α,3β-dihydroxyurs-5,12-dien-28-oic acid (13),2α,3β,23-trihydroxyurs-12-en-28-oic acid (14)和β-谷甾醇(15).化合物1～4,8～14为首次从该种植物中得到.其中木藜芦烷类二萜asebotoxin-III (1)为主成分之一,我们推测化合物1和其余两个木藜芦烷类二萜grayanotoxin-XVIII (2),leucothol A (3)为金叶子的活性成分,可能与该植物具有活络止痛的药效有密切的关系.

Investigation of the chemical constituents of the leaves of Craibiodendron yunnanense obtained the isolation of fifteen compounds. Their structures were elucidated as asebotoxin-Ⅲ （ 1 ）, grayanotoxin- ⅩⅧ （2）, leucothol A （3）, proA-4 （4）, quercetin-3-O-β-galactoside （5）, quercetin-3-O-α-arabino- furanoside （6）, quercetin-3-O-α- rhamnopyranoside （7）, trihydroxyflavone-3-O-α-rhamnopyranoside （8）, 2, 4-bis （4-hydroxyphengl）-1, 3-cyclobutane dicarboxglic aicd （9）, （Z）-p-hydroxy cinamic acid （10）, （E）-p-hydroxy cinamic acid （11）, vanillic acid （12）, 2ct, 313-dihydroxyurs-5, 12-dien-28-oic acid （13）, 2α, 3β, 23-trihydroxyurs-12-en-28-oic acid （14）, and β-stiosterol （15）. Compounds 1-4, and 8-14 were isolated from the titled plant for the first time. In addition, compounds 1-3 may have closed relationships with the effects of analgesic.