职业性苯中毒早期生物监测指标筛选探讨

STUDY ON THE EARLY BIOLOGICAL INDICATOR OF OCCUPATIONAL BENZENE POISONING

为探讨职业性苯中毒的早期监测指标，本实验对低于国家卫生标准的二个不同浓度下职业苯接触组的人群，测定了白细胞膜脂流动性（Ｌ），白细胞和血清丙二醛（ＭＤＡ）、血清超氧化物歧化酶（ＳＯＤ），丙氨酸转氨酶（ＡＬＴ）、硷性磷酸酶（ＡＫＰ）等生化指标以及白细胞（ＷＢＣ）、血小板（Ｐｔ）计数、血红蛋白（Ｈｂ）含量等传统指标；部分工人检测了尿液反，反－粘康酸（ｔ，ｔ－ＭＡ）含量。结果∶接触组的ＷＢＣ计数较对照组明显下降，接触组人群尿液ｔ，ｔ－ＭＡ显著升高，而白细胞膜脂流动性（Ｌ）及ＭＤＡ、ＳＯＤ、ＡＬＴ、ＡＫＰ在各组均未见明显改变。提示尿ｔ，ｔ－ＭＡ可作为长期低浓度苯接触人群的特异性监测指标。

It is attempt to find a early specific indicator of occupational chronic benzene poisoning. In this study, three different concentrations which benzene exposure population are all lower than MAC. They all have been measured such as leucocyte lipid mobility(L), Leucocyte MDA, Serum MDA and Superoxide dismutase (SOD), ALT,AKP in serum. Leucocyte and platelet count,hemoglobin content. Some workers have also been measured for example urinary t,t muconic acid(MA) content, After this experiment, the level of leucocyte count in exposure group was significantly lower thanthat in control group, but urinary t,t MA was increased significantly in exposured group. Other biochemical indicators had no significant change in all differentadministration concentration groups. It was suggested that urinary t,t MA may be specific indicator of exposure population contact with low concentration benzene for a long time. It has important clinic significance to find out early benzene influence.