摘要
目的:探讨流式细胞术(CD45/SSC设门法)检测恶性淋巴瘤骨髓受累的临床价值。方法:采用配对计数资料的实验设计,应用流式细胞仪对恶性淋巴瘤患者的骨髓标本进行检测,同时行骨髓涂片检查。结果:对34例恶性淋巴瘤患者的骨髓同时行上述两种方法检测,流式细胞术阳性率67.65%(23/34),95%可信区间(51.92%,83.37%),涂片法阳性率11.76%(4/34),95%可信区间(0.94%,22.58%)。经配对计数资料χ2检验,差别有统计学意义。结论:流式细胞术是检测恶性淋巴瘤骨髓受累的有效方法,检出率67.65%,优于传统的涂片法。
Objective： To study the value of flow cytometry （CD45/SSC gate） in detecting bone marrow involvement of malignant lymphoma. Methods： Paired data of chi-square test design was adopted. Bone marrow of malignant lymphoma patients was detected by Flow Cytometer and bone marrow smear was simultaneously performed. Results： The samples of the bone marrow in 34 patients with malignant lymphoma were examined by flow cytometer with smear. A total of 23 cases were detected the bone marrow involvement by flow cytometry and only four were found with bone marrow invasion by means of smear （X^2=17.05, P〈0.05）. Conclusions： flow cytometry is a feasible and effective method for detection in patients with bone marrow involvement. This method is super to conventional bone marrow smear.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2005年第20期1165-1167,共3页
Chinese Journal of Clinical Oncology
