肌苷增强蟾蜍离体单一肌梭传入放电频率

Effect of inosine on the discharge of isolated toad muscle spindle

目的探讨肌苷对肌梭传入放电的影响。方法用蟾蜍缝匠肌制备单一肌梭标本以空气隔绝法记录单一肌梭的传入放电,观察肌苷注射液对肌梭传入放电的影响。结果应用0.2 mmol/L0、.4 mmol/L0、.8 mmol/L肌苷后,肌梭的传入放电分别由(0.86±0.12)Hz、(0.88±0.12)Hz、(0.85±0.10)Hz增加至(11.42±2.48)Hz、(21.75±3.03)Hz、(32.25±4.08)Hz。结论肌苷可以使肌梭的传入放电频率明显增加,且呈剂量依赖关系。

Objective To observe the effect of inosine on afferent discharge of muscle spindle. Methods The afferent discharge of isolated toad muscle spindle was recorded using air±gap technique. The effects of inosine on the discharge rate of muscle spindle was observed. Results After administration of 0.2 mmol/L, 0.4 mmol/L and 0.8 mmol/L inosine, the spontaneous discharge of muscle spindle increased from （0.86 4± 0.12） Hz, （0.88 ± 0.12）Hzand （0.85±0.10）Hz to（11.42±2.48）Hz, （21.75±3.03）Hz and （32.25±4.08）Hz, respectively. CoNclusiON Inosine can increase the afferent discharge rate of muscle spindle, and this effect is dose-dependent.