灯盏花对上颌前牵引中骨缝成骨的影响

Effects of erigeron breviscapus on suture osteogenesis during maxillary protraction

目的观察灯盏花在上颌前牵引动物模型中对骨缝成骨的影响。方法16只兔随机分为实验组、对照组,每组各8只,两组动物均安置特制外置式牵引支架,向前持续弹性牵引。对照组于双侧前颌缝局部注射生理盐水,实验组则于局部注射灯盏花,每侧0.4 mL,每24 h注射1次。用序列四环素荧光标记法标记骨缝新形成的骨组织,荧光显微镜下观察,用计算机图像分析系统测量新骨量。结果实验组新骨形成的量明显大于对照组(P<0.05)。结论灯盏花在上颌前牵引动物模型中可加快骨缝新骨的形成。

Objective To understand the effects of Erigeron Breviscapus （EB） on suture osteogenesis during maxillary protraction in animal models. Methods The experiment was carried in 16 pubertal rabbits using self- made distraction devices during maxillary protraction, through which a forward elastic force （about 350 g ） was exerted. During maxillary protraction, the experimental group underwent Erigeron Breviscapus, injected about 0.4 mL at either side of premaxilla- maxillary suture every day, and the control group were injected physiological saline. Undecalcified tissue slices labeled by serial tetracycline fluorochrome for 28 days were prepared for examination of the newly formed bone by computer image analysis. The results were compared between the two groups. Results The quantity of newly formed bone was significantly different between the two groups. The experimental group showed more newly formed bones than the control group. Conclusion EB can promote suture osteogenesis during maxillary protraction in the model.