期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

乙酰肝素酶——癌症转移治疗的靶点 被引量：4

Heparanase: target for cancer metastatic therapy
下载PDF
导出
作者 赵华军 章雄文 丁健
机构地区 中国科学院上海生命科学研究院上海药物研究所国家新药研究重点实验室肿瘤药理组
出处 《药学学报》 CAS CSCD 北大核心 2005年第10期871-875,共5页 Acta Pharmaceutica Sinica
基金 科技部国家重点基础研究发展计划(973计划)项目(2003CB716404).
关键词 乙酰肝素酶 癌症转移 抑制剂 heparanase cancer metastasis inhibitor
分类号 R73-37 [医药卫生—肿瘤] R730.5 [医药卫生—肿瘤]
  • 相关文献

参考文献33

  • 1Pikas DS, Li JP, Vlodavsky I, et al. Substrate specificity of heparanases from human hepatoma and platelets [ J ]. J Biol Chem, 1998,273 (30): 18770 - 18777.
  • 2Parish CR, Freeman C, Brown K J, et al. Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity [ J ]. Cancer Res,1999,59(14) :3433 -3441.
  • 3Okada Y, Yamada S, Toyoshima M, et al. Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence [ J ]. J Biol Chem,2002,277 (45) :42488 - 42495.
  • 4Vlodavsky I, Friemann Y, Elkin M, et al. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis [ J]. Nat Med, 1999,5(7): 793 - 802.
  • 5Miao HQ, Ornitz DM, Aingorn E, et al. Modulation of fibroblast growth factor-2 receptor binding, dimerization,signaling, and angiogenic activity by a synthetic heparinmimickling polyanionic compound [ J ]. J Clin Invest,1997,99(7 ): 1565 - 1575.
  • 6Walch ET, Marchetti D. Role of neurotrophins and neurotrophins receptors in the in vitro invasion and heparanase production of human prostate cancer cells [J]. Clin Exp Metastasis, 1999,17(4) :307 -314.
  • 7Hulett MD, Freeman C, Hamdorf B J, et al. Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis [ J ]. Nat Med, 1999, 5 (7):803 - 809.
  • 8McKenzie E, Tyson K, Stamps A, et al. Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member [ J ]. Biochem Biophys Res Commun, 2000,276 ( 3 ): 1170 - 1177.
  • 9Uno F, Fujiwara T, Takata Y, et al. Antisense-mediated suppression of human heparanase gene expression inhibits pleural dissemination of human cancer cells [ J ]. Cancer Res, 2001,61 (21) :7855 - 7860.
  • 10张友磊,傅志仁,张军,王元和,沈茜.乙酰肝素酶反义寡核苷酸对人乳腺癌细胞株MDA435侵袭力的抑制作用[J].中华医学杂志,2003,83(3):204-207. 被引量：18

共引文献17

同被引文献23

  • 1Eikin M.Heparanase as mediator of angiogenesis:mode of action[J].FASEB J,2001,15(9):1661-1663.
  • 2Weidner N.Intratumor microvessel density as a prognostic factor in cancer[J].Am J Pathol,995,147:9-19.
  • 3Vaday GG,Lider O.Extraeellular matrix moie-ties,cytokines,and enzymes:dynamic effects on immune cell behavior and inflammation[J].J Leukoc Biol,2000,67:149-159.
  • 4Vlodavasky I,Elkin M,Pappo O,et al.Mammalian heparanase as mediator of tumor metastasis and angiogenesis[J].Isr Med Assoc J,2000,2(5):37 -45.
  • 5Gingis-Velitski S,Zeiser A,Flugelman MY,et al.Heparanase induces cell migration via protein kinase B/Akt activation[J].J Biol Chem,2004,279 (11):23536-23541.
  • 6Eikin M. Heparanase as mediator of angiogenesis : mode of action[ J]. FASEB J,2001,15(9) :1 661-1 663.
  • 7Vlodavsky I, Friedmann Y, Elkin M, et al. Mammalian hepara -nase: Gene cloning, expression and function in tumor progression and metastasis [ J ]. Nat Med, 1999,5 (7) :793-802.
  • 8Toyoshima M, Nakaiima M. Human heparanase [ J ]. J Biol Chem, 1999,274(34) :24 153-24 160.
  • 9Kussie PH, Hulmes JD, Ludwig DL, et al. Cloning and functional expression of a human heparanase gene [ J ]. Biochem Biophys Res Commun, 1999,261:183-187.
  • 10Castor CW, Kotlyar A, Edwards BE. Connective tissue activation ⅩⅩⅩⅧ [ J ]. J Rheumatol,2002,29 ( 11 ) : 2 337 -2 344.

引证文献4

二级引证文献6

药学学报
2005年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部