树枝状高分子在生物医学领域的应用研究进展

Development and Applications of Dendrimers in Biomedicine

树枝状大分子 (dendrim ers)是近年来出现的一类新型合成高分子 ,具有高度支化、结构规整、单分散等特性。这些特点使其在许多领域有潜在的重要应用价值 ,成为相关领域的研究热点。本文介绍了树枝状大分子的基本结构和合成路线 ,并对近年来国际上关于树枝状大分子在药物运载、DNA传递、特殊造影剂、肿瘤治疗新技术等生物医学领域的研究及应用探索进行了综述。

Dendrimers are new macromolecules synthesized in recent years, which are of great interests in many fields where they have potential important applications because of their hyperbranched, well defined and monodisperse structures. In this paper, the unique structures, general synthesis routes and basic physical and chemical properties of dendrimers are introduced in brief, and the progress in the research of dendrimers in drug （gene） delivery, contrast agents, cancer therapy were reviewed, as well as the perspective in research and applications.