工频磁场刺激小鼠MSCs体外增殖与分化的初步研究

Preliminary Research on the Proliferation and Differentiation of Rat Bone Marrow Mesenchymal Stem Cells with Exposure to 50 Hz Magnetic Fields

通过实验初步研究了工频磁场对小鼠骨髓间充质干细胞体外增殖与分化的影响。实验结果显示工频电磁场对骨髓间充质干细胞的增殖与分化有明显的诱导效应,且具有一定的重复性,同时,磁效应不是一种线性关系,存在着窗口效应。文末讨论了磁刺激治疗骨折不愈合研究的国内外现状,并提出了我们的研究构想。

A preliminary experimental research on the proliferation and differentiation of rat bone marrow mesenchymal stem cells with exposure to 50 Hz magnetic fields is done, The experimental results can be well repeated, showing that 50 Hz magnetic fields can evidently affect the proliferation and differentiation of rat bone marrow mesenchymal stem cells （MSCs）, besides, the results are not linear with the amplitude of magnetic fields, but existing therein a ＇window＇ phenomenon, At the end of this paper, the domestic and overseas development of the research is discussed on with the emphasis how to cure the bone fracture with the help of magnetic fields, and our investigative thoughts are also presented.