碳相成分对DLC薄膜血液相容性影响的能量机制

Energy Mechanism of Effects of Carbon Phase Components on Hemo compatibility for DLC

以6个不同工艺条件制备的DL C薄膜为样本,在前期碳相成分与表面能量参数测定、碳相成分和表面能量参数与血小板黏附特性关联分析的基础上,用T型关联度法,进一步对碳相成分和表面能量参数进行了灰色关联分析。结果显示:(1)在6个表面能量参数中,临界表面张力与碳相成分的整体关联最大,其次为表面张力的色散分量,其它则关联较小;(2 ) DL C碳相与临界表面张力和表面张力的色散分量有较大的负关联度(- 0 .5 7,- 0 .33) ,而与亲水性的其它表面能量参数的关联度均为小于0 .2 0的正值;(3) C- H碳相和C- O碳相与临界表面张力呈较大的正相关(0 .4 8,0 .2 5 )。据此得出分析结论:(1) DL C碳相主导DL C薄膜的血液相容性,其作用机制是对表面润湿性的强抑制和亲水性的有限增强;(2 ) C- H碳相和C- O碳相促使血小板变形的能量机制是增大DL C薄膜的临界表面张力;(3)评价DL C薄膜的血液相容性,既可用临界表面张力作指标设立标准,也可以对DL C碳相的含量要求、辅以对C- H碳相和C- O碳相的含量限定设立标准。本研究为用表面性质表征DL C薄膜的血液相容性提供了理论依据。

The correlations between surface energy parameters and carbon phase components in six diamond like carbon film （DLC） samples made in different ways and processing conditions were further investigated using the analysis of T-type correlation degree in the Grey system theory based on our earlier studies such as the determination of carbon phase and surface energy parameters, the analyses of carbon phase components, surface energy parameters and adhesive characteristic of platelets for DLC. The results showed： （1） as a whole, critical surface tension has the closest relation with carbon phase components, chromatic dispersion branch of surface tension takes the second place, but for the other four parameters, the correlation is weak; （2） DLC phase has larger negative correlation （degrees -0.57,-0.33） with critical surface tension and chromatic dispersion branch of surface tension, while its correlation degrees with the other four parameters related to polarity are all positive values smaller than 0.20; （3） C-H phase and C-O phase have larger positive correlation （degrees 0.48, 0.25） with critical surface tension. We have come to three conclusions; （1） DLC phase plays a dominant part in hemocompatibilioty of DLC by powerfully decreasing humidification and limitedly increasing polarity; （2） the energy mechanism of platelet deformation enhanced by C-H phase and C-O phase involves increasing the critical surface tension of DLC; （3） the hemocompatibility of DLC can be evaluated by using the critical surface tension as index and using the content of DLC phase and additional content limitation of C-H phase and C-O phase as standard. This study has provided a theoretical basis for evaluting the hemocompatibility of DLC based on surface properties.