200例玫瑰糠疹的临床特征及其与人类疱疹病毒6感染的关系

Clinical Characteristics of Pityriasis Rosea and the Correlation with Human Herpesvirus-6 Infection

目的分析玫瑰糠疹的临床特征及其与人类疱疹病毒6感染的关系,旨在提高对该病的诊疗水平。方法对200例玫瑰糠疹患者的临床资料进行回顾性分析,总结其发病特点;同时采用PCR法对其中44例急性期患者的血浆、外周血单核细胞(PBMC)、皮损、唾液标本中人类疱疹病毒6(HHV-6)的DNA进行检测。结果经对200例患者发病的分季统计显示,春、夏、秋季间玫瑰糠疹发病率无显著差异(均P>0.05),对皮损特点、分布情况和自觉症状统计发现存在不典型的皮损、不典型的分布部位与自觉症状的患者。此外,经PCR检测证实44例急性期患者中部分存在HHV-6感染。结论除春秋季外,夏季也是玫瑰糠疹的高发季节;其可表现为不典型的皮损、不典型的发病部位及伴有显著瘙痒,值得临床医师重视;其发病可能与HHV-6感染有关。

Objective To analyze the clinical characteristics of pityriasis rosea and their correlation with human herpesvirus-6 （HHV-6） infection to improve the diagnosis of this disease. Methods The clinical data of 200 cases of pityriasis rosea were retrospectively analyzed and the attack was summarized. At the same time, PCR method was used to detect the DNA HHV-6 in serum, peripheral blood mononuclear cells, skin lesions and saliva from 44 patients with acute pityriasis rosea. Results Seasonal statistical analysis on the attacks of 200 patients with pityriasis rosea revealed that the incidence of pityriasis rosea showed no significant difference among the seasons of spring, summer and autumn （P〉0.05）. In some patients, there were atypical skin lesions, distribution and spontaneous symptoms. In addition, PCR indicated that in 44 cases of acute pityriasis rosea, some had HHV-6 infection. Conclusion Besides spring and autumn, summer is the peak season of pityriasis rosea also. Pityriasis rosea presents atypical lesions, locations and severe pruritus. The pathogenesis of pityriasis rosea may be related with HHV-6 infection.