Rho激酶与脑血管痉挛被引量：21

Rho kinase and cerebral vasospasm

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摘要 Rho激酶是一类丝氨酸/苏氨酸蛋白激酶,它是小G蛋白Rho的下游作用底物,且可通过调节细胞骨架的组装、细胞粘附、细胞移动、平滑肌收缩和基因表达来发挥其生物学作用。以血管平滑肌异常收缩为特征的脑血管痉挛(CVS)是蛛网膜下腔出血(SAH)主要的并发症之一,尤其是动脉瘤性蛛网膜下腔出血致死致残的首要原因。Rho激酶主要通过抑制肌球蛋白轻链磷酸酶(MLCP)的活性来上调肌球蛋白Ⅱ的肌球蛋白轻链(MLC)磷酸化水平,进而以不依赖Ca2+的方式增强平滑肌收缩,参与CVS发生。有效抑制Rho激酶活性有可能为CVS的预防开辟一条新途径。 Rho kinase is a downstream effector of the small GTP-binding protein and Rho plays a pivotal role in many biological processes including cytoskeletal organization, cell adhesion, cellular migration, contraction of smooth muscle and gene expression. Cerebral vasospasm （CVS）characterized by the abnormal contraction of vascular smooth muscle has been one of the most important complications in subarachnoid hemorrhage （SAH）, especially exerting the leading cause of morbidity and mortality in aneurysmal subarachnoid hemorrhage. Rho kinase potentiates smooth muscle contraction mainly in a Ca^2＋ independent manner, but inhibits the activity of MLC phosphatase（MLCP）. This process contributes to the development of cerebral vasospasm, so efficient inhibition of Rho kinase may provide a clue for the treatment and prevention of CVS.

作者赵炜疆

机构地区首都医科大学研究生院

出处《基础医学与临床》 CSCD 北大核心 2005年第10期896-900,共5页 Basic and Clinical Medicine

关键词 RHO激酶 RHO 蛛网膜下腔出血脑血管痉挛 Rho Rho kinase subarachnoid hemorrhage （SAH） cerebral vasospasm

分类号 R743.3 [医药卫生—神经病学与精神病学]

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