淋巴瘤侵犯骨髓的骨髓活检病理学诊断研究进展

Advances of Bone Marrow Biopsy Pathology in Diagnosing Lymphoma Bone Marrow Involvement

淋巴瘤侵犯骨髓(lymphomabonemarrowinvolvement,LBMI)主要靠骨髓活检确诊。霍奇金淋巴瘤(Hodgkin蒺slymphoma,HL)、非霍奇金淋巴瘤(non-Hodgkin蒺slymphoma,NHL)侵犯骨髓各有其不同病理特点。骨髓中瘤细胞的形态特点、分布方式及免疫表型多数与髓外部位一致,少数又可存在差别。本文比较了各型HL、B-NHL、T-NHL的骨髓侵犯病理学特点,并从形态学、免疫组化及淋巴瘤基因重排检测三方面对LBMI的骨髓活检诊断研究进展进行了综述。

The diagnosis of lymphoma bone marrow involvement （LBMI） is mainly based on bone marrow biopsy. Pathology of LBMI in Hodgkin＇s lymphoma （HL） and non-Hodgkin＇s lymphoma （NHL） are different, The morphology, distribution patterns and immunophenotype of most tumor cells in bone marrow are consistent with those in extramedullary sites, but few may show some discrepancy. This article compared the pathologic features of LBMI in HL, B-NHL and T-NHL, and reviewed advances of bone marrow biopsy pathology in diagnosing LBMI from the aspects of morphology, immunohistochemistry, and lymphoma gene rearrangement,