盐酸氨基葡萄糖改善膝骨性关节炎症状的效果评估

Effect of glucosamine hydrochloride in ameliorating knee osteoarthritis 

目的:观察盐酸氨基葡萄糖胶囊改善膝骨性关节炎症状的有效性及其应用中出现的不良反应。方法:选择2004-04/09在复旦大学附属华山医院康复医学科门诊就诊的膝骨性关节炎患者20例,给予每例患者口服盐酸氨基葡萄糖胶囊2粒/次,3次/d,连续服用4周。采用以患者为试验对象的自身对照试验方法,观察20例患者(每例患者只观察一个患病关节)口服盐酸氨基葡萄糖胶囊治疗前、治疗4周后以及停药后1周的Lequesne指数得分的变化,并对20个患病关节治疗前、治疗4周后以及停药后1周的Lequesne指数得分平均值进行t检验。结果:20例患者均进入结果分析。①20例膝骨性关节炎患者20个患病关节,有17个患病关节的疼痛、压痛、肿胀、晨僵、步行能力等症状体征得到了有效改善,总有效率达到85%(17/20)。②20个患病关节治疗前、后Lequesne指数得分平均值分别为9.70±3.01和5.40±2.80,两者差异有非常显著性意义(P<0.001)。而且停药后1周,疗效仍能维持。③20例观察对象中,有5例发生轻度不良反应,均症状轻微,未影响治疗的正常进行。结论:盐酸氨基葡萄糖胶囊是一种有效改善膝骨性关节炎症状,且应用较为安全的药物。

AIM： To observe the therapeutic effectiveness of glucosamine hydrochloride capsule in ameliorating knee osteoarthritis, and the adverse reaction occurred during the application. METHODS： Twenty outpatients with knee osteoarthritis were selected from the Department of Rehabilitation Medicine, Huashan Hospital of Fudan University between April and September 2004. The 20 patients were treated with oral glucosamine hydrochloride capsule, two capsules for each time, three times a day for 4 continuous weeks. By means of self-control, the changes of the Lequesne index scores of one affected knee joint were observed before the treatment with glucosamine hydrochloride capsule, 4 weeks after treatment and 1 week after drug withdrawal, and the average values of the Lequesne index scores were analyzed with the t-test at the 3 time points respectively. RESULTS： All the 20 patients were involved in the analysis of results. ① Of the 20 affected joints in the 20 patients with knee osteoarthritis, the symptoms of pain, tenderness, swelling, stiffness in morning and walking difficulties were effectively ameliorated in 17 affected joints, and the total effective rate reached 85% （17/20）. ② Before and after treatment, the average values of the Lequesne index scores for the 20 affected joints had very significant differences （9.70±3.01, 5.40±2.80, P 〈 0.001）, and the effect could still maintain after drug withdrawal for 1 week. ③ Only 5 of the 20 subjects had mild side effects, the symptoms were mild, which did not affect the on-going of the treatment. CONCLUSION： Glucosamin hydrochloride capsule is effective and safe in treating knee osteoarthritis.