高分子聚乙烯颈椎融合器在山羊体内的应用(英文)

Application of the cervical fusion cage of high molecular weight polyethylene in goats

背景:颈椎病手术中常用钛合金颈椎融合器,但其出现下沉等情况常影响疗效。目的:观察自制高分子聚乙烯颈椎融合器在动物体内应用后的生物相容性和稳定性。设计:随机分组,观察对比实验。单位:郑州大学动物实验中心。材料:雌性未孕山羊20只,年龄在1.1～1.6岁。方法:实验于2001-06/11在郑州大学动物实验中心完成。①将山羊随机分为实验组10只,对照组10只。②实验组植入自制颈椎融合器,内填塞自体松质骨,对照组植入自体髂骨块。③6周后两组山羊分别摄X射线片观察椎间隙高度改变;并在麻醉状态下处死动物,将部分颈椎标本置于YJ-14生物力学试验机上测试抗压缩力、椎间隙高度及做病理学观察。主要观察指标:①两组抗压缩力测试及颈椎椎间隙的高度变化。②两组椎间融合处组织病理学观察结果。结果:①两组抗压缩力测试及颈椎椎间隙的高度变化:实验组压缩载荷显著大于对照组[(358.64±15.63),(268.82±11.36)N,P<0.05];两组相比椎间隙高度差异无统计学意义(P>0.05)。②两组椎间融合处组织病理学观察结果:实验组融合器周围组织切片有大量骨母细胞生长,与对照组无明显差别。结论:自制颈椎融合器具有很强的支撑力和良好的稳定性,可起到稳定颈椎间隙高度的作用。

BACKGROUND： Titanium cage of cervical vertebral fusion is often used during a surgical operation for cervical syndrome; however, it has a bad impact on the operative effect because of submerging. OBJECTIVE： To observe the biocompatibility and stability of cervical fusion cage of high molecular polyethylene in animals. DESIGN： A randomized grouping and observational control experiment. SETTING： The Animal Experimental Center of Zhengzhou University. MATERIALS： Twenty female goats without pregnancy at 1.1-1.6 years of age. METHODS： The experiment was conducted at the Animal Experimental Center of Zhengzhou University between June and November 2001. Twenty goats were equally randomized into experimental group and control group. Self-made cervical fusion cage filled with autogenous spongy bone was implanted into the goats in the experimental group, only autogenous lilac bone was implanted in the control group. X-ray for observing the changes in the height of intervertebral space was performed in two groups 6 weeks later. All the animals were killed under anesthesia to extract cervical vertebra samples, which were placed on YJ-14 Biomechanical Tester to measure anti-compression ability and height of intervertebral space and to observe pathological changes. MAIN OUTCOME MEASURES： ① Anti-compression ability test and height of intervertebral space; ② Pathological changes in fusion tissue. RESULTS： ① Anti-compression ability and height of intervertebral space： Compression loading in the experimental group was significantly higher than that in the control group [（358.64±15.63）,（268.82±11.36）N, P 〈 0.05]; however, there was no difference in the height of intervertebral space between the two groups （P 〉 0.05）. ② Pathological changes： A great amount of osteoblasts were found in the tissues around the cage in the experimental group, but there was no difference between the two groups. CONCLUSION： The self-designed cervical vertebral fusion cage possesses high upholding strength, good biocompatibility and stability and can play a role in stabilizing the height of intervertebral space.