经导管封堵治疗50例室间隔缺损的疗效和安全性

Therapeutic effect and safety of transcatheter occlusion of ventricular septal defects in 50 patients

目的:观察应用室间隔缺损封堵器经导管介入封堵先天性室间隔缺损(VSD)的疗效和安全性.方法:50例VSD患者术前由经胸超声心动图确诊,在透视及经胸超声心动图监视下经导管置入室缺封堵器封堵VSD,术后1, 3, 6个月分别行经胸超声心动图、心电图评价治疗效果.结果:50例VSD患者术中经左心室造影明确缺损直径为1.8～13.4(5.54±2.75) mm,封堵成功率96.0%(48/50),手术并发症发生率为16.7%(8/48),封堵术后3个月超声复查左室舒张末径较术前明显缩小.结论:经导管封堵VSD是一种成功率较高、并发症少、创伤小、疗效可靠的介入治疗方法.

Objective To determine the therapeutic effect and safety of transcatheter closure of ventricular septal defects （VSD） in 50 patients. Methods Fifty patients were diagnosed by transthoracic echocardiography. To perform the operation, transthoracic echocardiography and X ray were used continuously to monitor the procedure. Transthoracic echocardiography and ECG were performed at 1,3, and 6 months after the operation to evaluate the therapeutic effect. Results The VSD diameter ranged from 1.8 to 13.4 （5.54 ±2.75 ） mm . The successful rate of the operation was 96.0% , and the complication rate of the operation was 16.7%. A 3 month follow-up was completed in 20 patients, and the median left ventricle end-diastolic dimension significantly decreased from （40.20 ± 8.80） mm to （32.90 ± 8.36） mm （P 〈 0. 001 ）. Conclusion Transcatheter closure of ventricular septal defects is a good method with a high success rate of placement, fewer complications, and a good occlusion effect.