摘要
目的探讨18F-脱氧葡萄糖(FDG)符合线路显像在卵巢上皮性癌术后监测中的价值。方法对33例卵巢上皮性癌术后临床完全缓解6个月以上患者进行18F-FDG符合线路显像,经有序子集最大期望值法(OSEM)同时重建衰减与无衰减校正断层图像,用感兴趣区(ROI)技术计算病变/正常组织比值(L/B)。并与同期CT、B超结果和血清CA125水平比较。20例施行2次探查术或再次肿瘤细胞减灭术的患者以病理学检查结果进行评判,13例未再次手术者以随访和其他检查结果进行评估。结果18F—FDG符合线路显像24例患者发现异常放射性浓聚灶,3例假阳性。衰减与无衰减校正图像L/B分别为4.9±4.3和4.2±4.0。9例未见异常放射性浓聚灶,4例假阴性。其灵敏度、特异性、准确性、阳性预测值和阴性预测值分别为84.0%、62.5%、78.8%、87.5%和55.6%。与CT、B超结果比较,准确性差异有显著性(x2=4.89、5.0,P均<0.05)。结论18F-FDG符合线路显像能弥补其他影像学检查的不足,增加诊断信息。
Objective To evaluate the diagnostic efficacy of ^18F-fluorodeoxyglucose （FDG） SPECT imaging for detecting recurrence in postoperative epithelial ovarian carcinoma. Methods This study included 33 patients after optimal cyto-reductive surgery and sufficient chemotherapy, with clinical remission more than 6 months, 20 patients after second exploration or cyto-reductive surgery were evaluated with pathologic study, and 13 patients not operated were evaluated with other methods. The raw data with attenuation correction （AC） and non attenuation correction （NAC） were reconstructed iteratively, and the ratios of lesion to background （L/B） were calculated with the region of interest （ROI） method. The CT, B-uhrasonography and CA125 level in plasma were also measured. Results Lesions with high ^18F-FDG uptake were detected in 24 patients and false ^18F-FDG uptake in 3 patients. The L/B ratios of AC and NAC images were 4. 9±4.3 and 4.2 ±4.0, respectively. 9 patients showed no abnormal uptake in ^18F-FDG SPECT images and 4 patients were false negative. The sensitivity, specificity, accuracy, positive and negative predictive value of ^18F-FDG SPECT imaging were 84.0%, 62.5%, 78.8%, 87.5% and 55.6%, respectively. There were significant differences in the accuracy of ^18F-FDG SPECT imaging with CT and B-uhrasonography. Conclusion ^18F-FDG SPECT imaging is useful for diagnosis of recurrence in epithelial ovarian carcinoma and can give additional information other than CT and B-uhrasonography.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2005年第5期270-273,共4页
Chinese Journal of Nuclear Medicine
