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碱性成纤维细胞生长因子在肌腱组织工程中的应用 被引量：5

THE APPLICATION OF BASIC FIBROBLAST GROWTH FACTOR IN TENDON TISSUE ENGINEERING
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摘要 目的综述近年来碱性成纤维生长因子(basicfibroblastgrowthfactor,bFGF)在组织工程肌腱相关研究中的进展。方法广泛查阅国内外相关文献,进行整理、综合与分析。结果bFGF在促进组织工程肌腱标准细胞系的建立,诱导支架材料的合成与降解,增强细胞与支架材料之间的相互作用,加速组织工程材料的再血管化等方面均有明显作用。结论促进内源性bFGF合成、控释外源性bFGF及提高bFGF的生物利用度等方面取得的进展,为bFGF在组织工程中的应用开辟了良好的应用前景。 Objective To review the recent researches of basic fibroblast growth factor （bFGF） in tendon tissue engineering, Methods Recent original related literature was extensively reviewed and analyzed, Results bFGF played an important role in establishing standard tendon tissue engineering cell lines, inducing the compound and analysis of extracellular matrix, enhancing interactions between cells and extracellular matrix and accelerating tissue engineering materials＇ neovascularization. Conclusion The progresses in increasing endogenetic bFGF expression, controlling the release of exogenous bFGF and improving the bio-utilization of bFGF has laid foundation for wider use of bFGF in tendon tissue engineering.
作者 郝鹏 项舟 杨志明
机构地区 四川大学华西医院骨科
出处 《中国修复重建外科杂志》 CAS CSCD 北大核心 2005年第11期915-918,共4页 Chinese Journal of Reparative and Reconstructive Surgery
基金 国家自然科学基金重点资助项目(30271317)~~
关键词 组织工程 碱性成纤维细胞生长因子 肌腱 Tissue enginecring Basic fibroblast growth factor Tendon
分类号 R318.0 [医药卫生—生物医学工程]
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参考文献26

  • 1Richardson TP,Trinkaus-Randall V,Nugent MA.Regulation of basic fibroblast growth factor binding and activity by cell density and heparan sulfate. J Bio Chem, 1999, 274(19):13534-13540.
  • 2Zuber ME,Zhou Z,Burrus LW,et al.Cysteine-rich FGF receptor regulates intracellular FGF-1 and FGF-2 levels. J Cell Physiol, 1997, 170(3):217-227.
  • 3Tang JB, Xu Y, Ding F, et al. Tendon healing in vitro: Promotion of collagen gene expression by bFGF with NF-kappaB gene activation . J Hand Surg Am, 2003, 28(2):215-220.
  • 4Tsutsumi S, Shimazu A, Miyazaki K, et al. Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Biochem Biophys Res Commun, 2001, 288(2):413-419.
  • 5Salingcarnboriboon R, Yoshitake H, Tsuji K, et al. Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property. Exp Cell Res, 2003, 287(2):289-300.
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  • 8万伟东,杨松林,高春芳,章庆国,林子豪.碱性成纤维细胞生长因子拮抗转化生长因子-β_1对人α1(I)胶原基因的启动激活[J].中国修复重建外科杂志,2002,16(6):401-403. 被引量：7
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二级参考文献25

  • 1Allman AJ, McPherson TB, Merrill LC, et al. The Th2-restricted immune response to einogenic small intestinal submucosa does not influence systemic protective immunity to viral and bacterial pathogens. Tissue Eng, 2002, 8(1):53.
  • 2Raeder RH, Badylak SF, Sheehan C, et al. Natural anti-galactose alpha 1, 3 galactose antibodies delay, but do not prevent the acceptance of extracellular matrix xenografts. Transpl Immunol,2002,10(1):15.
  • 3McPherson TB, Liang H, Record RD, et al. Galalpha(1,3)Gal epitope in porcine small intestinal submucosa. Tissue Eng, 2000;6(3); 233.
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  • 9Hodde JP, Record RD, Tullius RS, et al. Retention of endothelial cell adherence to porcine-derived extracellular matrix after disinfection and sterilization. Tissue Eng, 2002,8(2):225.
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共引文献48

同被引文献114

引证文献5

二级引证文献22

中国修复重建外科杂志
2005年 第11期

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