右旋糖酐基水凝胶药物控释体系的应用研究

APPLICATION RESEARCH ON DEXTRAN-BASED HYDROGEL AND ITS DRUG CONTROLLED RELEASE SYSTEM

目的介绍右旋糖酐基水凝胶在药物缓/控释和组织工程领域中应用的研究概况。方法广泛查阅近年来国内外相关文献,进行回顾与综合分析。结果右旋糖酐基水凝胶的应用研究在国际上已取得明显进展,但在国内才刚起步。右旋糖酐基智能水凝胶作为一种崭新的生物材料,已成为缓/控释给药和组织工程研究的热点之一。结论右旋糖酐基水凝胶是一种新型生物材料,在药物缓/控释和组织工程领域具有广阔的应用前景;通过化学修饰改性后的右旋糖酐基水凝胶可实现“智能”化,具有潜在的研究与应用价值。深入进行其赋性、改性研究并进行相关产品的产业化是未来右旋糖酐基生物材料的研究方向。

Objective To introduce the development of dextran-based hydrogel and its drug delivery system in drug sustained and/or controlled release, and to investigate their application in tissue engineering. Methods Related literature was extensively reviewed and comprehensively analyzed. Results In recent years, great progress was made in the studies of dextran-based hydrogels and study on dextran-based intelligent materials became an investigative hotspot especially in tissue engineering. Conclusion Dextran-based hydrogel is considered to be a good potential material in field of drug delivery and tissue engineering. Endowed with new characteristics, a series of intelligent biomaterials can be derived from dextran-based hydrogels, which can be widely used in biomedicine. Further study should be done on the industrialization of its interrelated production.