胎儿胸腺细胞悬液腹腔移植防治内源性哮喘临床及免疫学研究

Clinical and laboralory study on the effect or abdomal cavity transplantion of fetal thymic cells on endogenous asthma in children

报告用胎儿胸腺细胞悬液移植注射防治内源性哮喘患儿３４例。结果：治愈６７．６５％，显效２６．４７％，有效２．９４％，与胸腺素组（治愈６０％，显效２２．８６％，有效１１．４３％）比较无显著性差异（Ｐ＞０．０５），与常规治疗组（治愈０％，显效２５％，有效４０．６３％）比较总有效率和治愈率均有非常显著性差异（Ｐ＜０．０１）。患儿ＣＤ＿３、ＣＤ＿８明显低于正常对照组（Ｐ＜０．０１），ＣＤ＿４轻微升高（但Ｐ＞０．０５）．ＣＤ＿４／ＣＤ＿８明显高于正常对照组（Ｐ＜０．０１），提示患儿存在细胞免疫功能不全和免疫调节紊乱。经胎儿胸腺治疗后３个月患儿细胞免疫功能恢复正常，与正常对照组比较Ｐ＞０．０５。这些结果提示：胎儿胸腺具有调节机体细胞免疫功能，防治内源性哮喘反复发作的作用，且方法简单、安全，可作临床上一种防治手段。

children with endogenous asthma were treated with the suspension of fetal thymus cells transplanted into the palient's abdominal cavity preventing recurrent attacks.All cases were followed up for more than 2 years.The results showed that the cure rate and notable effective rate and effective rate were 67.65%、26.47%and 2.94% respectively.There was no significant difference as compared with the thymosin group(cure rate:60%,notable effective rate:22.86%,effective rate:11.43%)(P>0.05).Compared with the normal therapy group, whose cure rate and overall effective rate were 0% and 65.63% respectively,there were significant difference between two(P<0.01).T cell subset(CD3、CD4、CD8)were determined,CD3 showed significant decrease.CD4/CD8 showed significant increase.The Present study suggested that there might be dysfunction of cellular immunity.After 3 months of treatment,all the patienl's celluar immunity was the same as normal childrens(P>0.05).The result showed that was able to restore the function of cellular immunity and prevented recurrent attacks.That is considered to be reliabilie,simple and safe and could become an effective therapy in clinic for preventing endogenous asthma in children.