骨髓基质干细胞及其在骨组织工程中的应用

Biological properties of bone marrow stromal cells and their application in bone tissue engineering

骨髓基质干细胞(BMSCs)是一群存在于骨髓中的非造血干细胞,具有较强的自我更新能力和多向分化潜能,在体外不同的诱导条件下可分化为骨细胞、软骨细胞、肌腱细胞、脂肪细胞、神经细胞、平滑肌细胞等多种细胞。BMSCs的应用是目前国际上骨组织工程领域的重要研究内容,具有广泛的临床应用前景。近年来,许多实验室从分子、生化、物理等水平对其成骨分化调控进行了深入研究,取得了较大的进展。

Bone marrow stromal cells （BMSCs） are a population of none-hematopoietic stem cells residing in bone marrow. They have good self-renewal and multi-differentiating capacity and can be induced into a variety of connective tissue cells in vitro, such as osteocytes, chondrocytes, tenocytes, adipocytes, nerve cells and smooth muscle cells. Applications of BMSCs have been an important subject of investigation in the field of bone tissue engineering internationally, and have good prospects in clinical use. More studies on the regulation of osteogenic differentiation of BMSCs have been carried out at molecular, biochemical, physical levels and great progress have been made.