双生子人群apoAⅠ和apoB100水平及遗传度分析

Level and heritability analysis of serum apoAⅠ and apoB100 in twins

目的:描述双生子人群的apoAⅠ、apoB100水平,并探讨遗传和环境因素对其水平的影响程度。方法:选择双生子502对,采用免疫透射比浊法检测血清apoAⅠ、apoB100水平。在基因法卵性鉴定的基础上,结合年龄和性别因素,用最大似然法在Mx程序包进行遗传模型拟合。结果:本双生子人群包括同卵双生子329对,异卵双生子173对。apoAⅠ水平为(1.33±0.23)g/L,apoB100水平为(0.75±0.19)g/L。apoAⅠ的最适模型为AES模型,apoB100的最适模型为等级效应性别限制AE模型。遗传方差在apoAⅠ中所占的比重为60%;在apoB100中所占的比重为69%。结论:在本双生子人群中,apoAⅠ的遗传度为60%,apoB100的遗传度为69%。

Objectives： To describe the serum level of apoA Ⅰ and apoB100 in twins, and study the contribution of genetic and environmental effects to them. Methods： The researchers used immunoturbidimetric assay （ITA） for quantification of the serum apoA Ⅰ and apoB100 in 329 monozygotic （MZ） and 173 dizygotic （DZ） twins identified by genotyping. Mx was used to fit a variety of genetic models covering age and sex for the variation of apoA Ⅰ and apoB100. Results： The serum levels were （ 1.33±0.23） g/L for apoA Ⅰ and （0.75±0.19） g/L for apoB100. Model AES fitted apoAI data best and scalar effects sex-limitation model AE fitted apoB100 best. 60% of the variance in apoA Ⅰ was due to additive effects and 69% in apoB100. Conclusion： The heritability of apoA Ⅰ and apoB100 in this twin study was 60% and 69%.