前S1及其抗体在急性HBV感染中的表现

The manifestation of pre-S_1 antigen and antibody in acute HBV infection

以合成前Ｓ１肽及其单克隆抗体作试剂，建立酶免疫试验，检测急性乙肝病毒感染者的血清抗体转换。在急性乙型肝炎１８例中，前Ｓ１抗原和抗体的检出率分别为８８．８％和９４．４％；在一过性无症状乙肝病毒携带的２１例中，仅有１９．１％和３８．１％，提示与病变活动性密切相关。前Ｓ１抗体先于其它抗体出现，但仅持续５～４８周。

Abstract Using preS1 peptide and its raised antibody as reagents,the enayme immunoassays were developed to test The preS1 seroconversion during acute hepatitis B virus infections.In 18 cases of acute hepatitis B,the prevaLence of preS1 antigen and antibody were 88,8% and 94.4%respecively; while in 21 cases of transiant asymptomatic HBV carriers those were 19.1% and 38.1%,suggesting the close relationship with disease activity. The appearance of anti-preS1 was earlier the other HBV antibodies,but shortly existed with a medium only 14 weeks.