摘要
为探讨阿司匹林对冠心病患者合适的治疗剂量,采用抗人血活性血小板α颗粒膜蛋白140(GMP-140)特异单克隆抗体125I-SZ-51测定不稳定心绞痛患者,每日服用阿司匹林50mg(27例)、150mg(26例)、300mg(30例)治疗前和治疗7天后三组血小板膜表面GMP-140分子数,并常规计数血小板数目。结果显示阿司匹林治疗后血小板膜表面GMP-140分子数明显降低,而血小板数目明显升高,并且随着阿司匹林剂量的增加,两者的变化程度也增大(P值均<0.01),当剂量达300mg时,前者低于健康人组(P<0.005),后者已达健康人组水平(P>0.05)。三组阿司匹林剂量的近期副作用差别则无显著性。表明用该药治疗不稳定性心绞痛患者开始采用每日300mg的剂量是合理的。
Thenumberofalpha-granulemembraneprotein140(GMP-140)moleculeswasdetectedbyusingspecificmonoclonalantibodies(125I-SZ-51)againstGMP-140inthreegroupsofpatientswithunstableanginatreatedwithasprin50mg(n=27),150mg(n=26)and300mg(n=30)adaybeforeand7daysaftertreatment.Thenumberofplateletswascountedbyusingtheroutinemethod.Theresultsindica-tedthatthenumberofGMP-140moleculesdecreasedsignificantlyandthenumberofplateletsin-creasedsignificantlyaftertreatmentwithaspirin.Withtheincreaseofaspirindosagethedegreeofthesetwochangesincreased(P<0.01,both)too.When300mgofaspirinwasused,thenumberofGMP-140moleculeswaslowerthanthatinacontrolgroupofhealthysubjects(P<0.005)andthenumberofplateletsreachedthatofthecontrolgroup(P>0.05).Therewasnodiferenceontheimmediatesideef-fectswhenthesethreedosagesofaspirinwereused.Theauthorsoftheopinionarethatitisrationaltouse300mgofaspirintotreatpatientswithunstableanginaatthebeginning.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1996年第8期524-526,共3页
Chinese Journal of Internal Medicine