摘要
为了解空腹血糖（ＦＢＧ）水平对非胰岛素依赖型糖尿病（ＮＩＤＤＭ）发病的预测价值，对１９８６年６３８例非糖尿病人群（糖耐量正常３４１例，糖耐量低减２９７例）于１９９２年进行血糖复查。结果发现，随着初访时ＦＢＧ水平增高，６年后ＮＩＤＤＭ发病率逐步增加。ＣＯＸ成比例风险模型分析，在调整了年龄、性别和体重指数的影响后，在糖耐量低减组ＦＢＧ仍与ＮＩＤＤＭ发病显著正相关（Ｐ＝０．０００１），ＦＢＧ均值为５．１９ｍｍｏｌ／Ｌ亚组与均值４．６１ｍｍｏｌ／Ｌ亚组相比，ＮＩＤＤＭ发病危险已有显著差异（ＲＲ２．１，９５％可信区间１．１９～３．７４，Ｐ＝０．０１）。ＦＢＧ均值为６．５０ｍｍｏｌ／Ｌ组，ＮＩＤＤＭ发病危险更高（ＲＲ２．９，９５％可信区间１．７９～４．５９，Ｐ＝０．０００１）。
Inordertoinvestigatethepredictablevalueoffastingbloodglucose(FBG)levelfortheincidenceofnon-insulin-dependentdiabetesmelitus(NIDDM),638nondiabeticsubjectswhowerein-vestigatedin1986(including341subjectswithnormalglucosetoleranceand297subjectswithimpairedglucosetolerance)werereexaminedin1992.Theresultsshowedthatthe6-year-incidenceofNIDDMwassignificantlyincreasedwithrisingofbaselineFBGlevel.Afteradjustingforage,sexandbodymassindex(BMI),proportionalhazardregressionanalysisshowedthatFBGlevelinimpairedglucosetoler-ancegroupwaspositivelyassociatedwiththedevelopmentofNIDDM(P=0.0001).SubjectswithmeanFBGlevelof5.19mmol/LhadahigherriskofdevelopingNIDDMthansubjectswithmeanFBGlevelof4.61mmol/L(RR2.1,95%CI1.19～3.74,P=0.01).TheriskratioofNIDDMwasfurtherincreasedinthegroupwithmeanFBGlevelof6.5mmol/L(RR=2.9,95%CI1.79～4.59,P=0.0001).TheresultindicatesthatFBGlevelisanindependentriskfactorforthedevelopmentofNIDDM.
出处
《中华内科杂志》
CSCD
北大核心
1996年第9期612-615,共4页
Chinese Journal of Internal Medicine
关键词
血糖
糖尿病
NIDDM
预测
BloodglucoseDiabetes-melitus
non-insulin-dependent
