基于图像投影的基因芯片图像网格定位

A Gene-chip Image Grid Localization Method Based on Profiles of Image

对基因芯片图像进行网格定位是芯片分析的前提和关键。利用芯片图像在水平方向和竖直方向的投影,可将二维图像分析问题转化为一维信号处理问题。本文对图像的投影信号进行算术平均滤波,然后利用不同参数滤波后投影信号间的灰度偏差进行网格定位。实验表明该方法对芯片信号点的定位有很高的准确性,且算法简单易行。

Automatic gene-chip image grid localization is an essential task for gene-chip image analysis. Now an method based on profiles of gene-chip image is proposed. Using the differences between two profiles after filtration by arithmetic mean method, we can easily find the local grayscale minimum between two probe spots, then the probe spots are automatically located. The experiments show that the new approach correctly locates the probes while giving protection against noise affection robustly.