DNA序列数值映射方法的研究

Study of Numerical Mapping Methods for DNA Sequences

DNA序列的数值映射是用数学方法、物理方法和数字信号处理方法分析生物分子序列首先要解决的问题。本文分析了现有8种DNA序列数值映射方法的特点和适应性。在此基础上,提出了一种基于DNA序列中碱基出现概率的数值映射方法。大多数蛋白编码序列具有3-碱基周期特性(周期-3性质)。借助于具有周期-3性质的DNA序列的频谱分析,比较了8种数值映射方法的优劣,并证实了新方法的有效性。计算机仿真结果表明,基于复域的映射方法无论从携带原有生物分子序列的信息量,还是数值映射后所得功率谱的效果均优于其它7种映射方法,而DNA序列新数值映射方法能够获得与复域法几乎相同的识别率。

The first problem to be solved is to map DNA sequences onto numerical sequences in bio - molecular sequence analysis by mathematical, physical and digital signal processing methods. The characters and the adaptability of eight existing mapping methods are analyzed in this paper. A new numerical mapping method based on the probability of bases in the segment DNA sequence is presented. Most of the coding sequences are characterized by 3 - base periodicity. Further more, eight numerical mapping methods are compared and the new method is verified by means of the spectrum analysis of DNA sequence with 3 - base periodicity. The computer simulation results show that the mapping method based complex plane is superior to the other seven methods in reflecting the original information of the bio-molecular sequence and the quality of the obtained power spectra. The identification rate the new method attains is approximately what the complex plane method has achieved.