1Burns DM. Primary prevention, smoking, and smoking cessation: implications for future trends in lung cancer prevention. Cancer,2000,89(11):2506-2509.
2Khuri FR, Lippman SM. Lung cancer chemoprevention. Semin Surg Oncol,2000,18(2):100-105.
3Bellacosa A, Testa JR, Staal SP, et al. A retroviral oncogene, akt, encoding a Serine/Threonine kinase containing an SH2-like region. Science,1991,254(5029):274-277.
4Thomas CC, Deak M, Alessi DR, et al. High-resolution structure of the pleckstrin homology domain of protein kinase B/Akt bound to phosphatidylinositol (3,4,5)-trisphosphate. Curr Biol,2002,12(14):1256-1262.
5Testa JR, Bellacosa A. Akt plays a central role in tumorigenesis. PNAS,2001,98(20): 10983-10985.
6Cantley LC. The phosphoinositide 3-kinase pathway. Science,2002,296(5573):1655-1657.
7Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/AKT-a major therapeutic target. Biochim Biophys Acta,2004,1697(1-2):3-16.
8Nicholson KM,Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal,2002,14(5):381-395.
9Qiu GR, Chen J, Kirn D, et al. An essential role for Rac in Ras transformation. Nature,1995,374(6521):457-459.
10Nimual AS, Yatsula BA, Bar-Sagi D. Coupling of Ras and Rac guanosine triposphatases through the Ras exchanger Sos. Science,1998,279(5350):560-563.
