VEGF、ER、PR在异位和在位子宫内膜中的表达

The Expression of VEGF,ER,PR in Ectopic Endometrium and Eutopic Endometrium of EM Patients

研究血管内皮因子(VEGF)、雌激素受体(ER)和孕激素受体(PR)在子宫内膜异位症(EM)患者的异位和在位内膜中的表达.采用免疫组化SP法分别检测45例EM(研究组)的异位和在位内膜及32例子宫肌瘤(对照组)的在位内膜中VEGF、ER、PR的表达.利用图像分析仪测定的相应密度代表其表达强度.研究组异位和在位内膜中VEGF的表达均显著高于对照组内膜(p<0.01),ER/PR则显著低于对照组内膜;ER、PR仅于异位内膜中的表达低于对照组内膜,异位内膜中VEGF与ER呈正相关.异位内膜和在位内膜中高VEGF和低ER/PR以及异位内膜中VEGF与ER正相关的特点可能与EM的发生发展有关.

This paper studies the expression of VEGF,ER and PR in ectopic and eutopic endometrium in patients who suffer from endometriosis. Using immunohistochemistry SP method, we examine respectively the expression of VEGF, ER and PR in ectopic and eutopic endometrium of 45 EM cases （study group）, and the expression of VEGF,ER and PR in eutopic endometrium of 32 cases of uterine fibroid （control group）. Image dissector shows that the corresponding density represents its expression intensity. The expression of VEGF is remarkably higher in the ectopic endometrium and eutopic endometrium of study group than the endometrium of control group （p〈0.01） ER/PR are remarkably lower than the endometrium of control group. ER and PR are lower than the endometrium of control group only in the expression of ectopic endometrium while VEGF in ectopic endometrium is positively related to ER. The high VEGF and low ER/PR in ectopic and eutopic endometrium, together with the fact that VEGF and ER are positively related in ectopic endometrium, may be the cause of the pathogenesis of EM.