Bcl-2、Bax在狼疮肾炎患者肾组织中的表达及意义

The study of the expression of Bcl-2 and Bax in renal tissues of patients with lupus nephritis

目的研究细胞凋亡调节蛋白(Bcl-2及Bax)在狼疮肾炎(LN)患者肾组织的表达情况及与LN肾脏病理改变的关系。方法2003-012003-04对广西医科大学第一附属医院的44例活动期LN患者用免疫组化方法检测肾组织中Bcl-2、Bax的表达,观察它们与LN肾脏病理改变的关系。结果(1)LN肾小球Bcl-2及Bax表达均增高,与肾小球细胞增殖程度及增殖细胞核抗原(PCNA)阳性细胞数呈正相关。(2)LN肾间质Bcl-2表达增高,与间质炎症细胞浸润程度正相关。(3)LN肾小管Bax表达增高,与肾小管间质病变呈正相关。结论LN肾组织存在Bcl-2、Bax蛋白异常表达。Bcl-2高表达在LN肾小球细胞增殖及肾间质炎症细胞浸润过程中可能起重要作用。Bax在肾小管过度表达与肾小管间质病变有关。

Objective To investigate the expressions of Bcl - 2 and Bax protein in the renal tissues of patients with lupus nephritis （LN） and their role in the pathology alteration of LN. Methods During 2003 - 01 - 2003 - 04 immunohistochemical staining was used to detect the expressions of Bcl - 2 and Bax in renal tissues of 44 cases of LN in the First Affiliated Hospital of Guangxi Medical University. Their relationship with pathology was also observed. Results （ 1 ） The expression of Bcl -2 and Bax was significantly increased and both were positively correlated with the grade of intraglomerular cell proliferation and proliferating cell nuclear antigen （PCNA） positive glomerular cells. （2） The expression of Bcl -2 in interstitial cells was significantly increased and positively correlated with the degree of interstitial infil- tration of inflammatory cells. （ 3 ） The expression of Bax in the tubule of LN was increased and was positively associated with tubulointerstitial lesions. Conclusion There is abnormal expressions of Bcl - 2 and Bax in renal tissues of LN. Overexpression of Bcl - 2 in renal tissues of LN might play an important role in the process of glomerular hypercellularity and interstitial infiltration of inflammatory cells. Overexpression of Bax in tubular ducts is correlated with tubulointerstitial lesions.