过敏性紫癜患儿血管内皮生长因子变化的意义

Changes of Serum Vascular Endothelial Growth Factor in Children with Henoch - Schonlein Purpura

目的探讨过敏性紫癜(HSP)患儿血清血管内皮生长因子(VEGF)水平的变化及其在HSP发病中的作用。方法采用双抗体夹心ELISA检测20例急性期HSP患儿、15例恢复期HSP患儿及15例正常儿童血清VEGF水平。结果急性期HSP患儿血清VEGF水平(533.85±127.63)ng/L,明显高于恢复期(160.47±37.39)ng/L及正常对照组(68.93±19.16)ng/L,差异具有显著性(F=158.86P<0.01),3组间作两两比较差异均具有显著差异(P均<0.01)。结论HSP患儿急性期血清VEGF水平明显升高,提示VEGF可能参与HSP的发病过程,可能在HSP发病机制中具有重要意义。

Objective To investigate the changes of serum vascular endothelial growth factor （VEGF） and its effects on pathoge nesis in children with Henoch- Schonlein purpura（HSP）. Methods Serum VEGF was detected by sandwich ELISA in 20 children with HSP in acute phase and 15 children in remission phase and 16 normal children. Results The serum VEGF levels in children with HSP in acute phase（533.85 ± 127.63） ng/L were significantly higher than those in remission phase （ 160.47 ± 37.39） ng/L and normal control （68.93 ± 19. 16） ng/L. One - way analysis of variance between them was significant difference （ F = 158.86 P〈0.01 ）. Conclusion The serum VEGF level increases markedly in acute phase of HSP, which shows that VEGF may play an important role in pathogenesis of HSP.