肾脏病患儿随机尿蛋白/尿肌酐比值的临床应用

Clinical Application of Spot Urine Protein/Creatinine Ratio in Children with Renal Disease

目的观察肾脏病患儿24h尿蛋白(24hUp)与随机尿蛋白/尿肌酐比值(Up/Ucr)的相关性,探讨采用随机尿Up/Ucr代替24hUp的可行性。方法162例肾脏病患儿分别留取24h尿和随机尿及血标本测定血、尿肌酐和尿蛋白,并分析随机尿Up/Ucr与24hUp的相关性。结果按肌酐清除率(Ccr)将肾脏病患儿分为4组,Ccr80～147mL/min、50～80mL/min、10～50mL/min、3～10mL/min。各组随机尿Up/Ucr与24hUp的相关系数分别为0.86、0.93、0.74、0.19。结论当Ccr>10mL/min时,随机尿Up/Ucr与24hUp有良好的相关性,可代替24hUp用于临床尿蛋白程度的监测。

Objective To determine the correlation of the spot urine protein to creatinine ratio （Up/Ucr） with urine protein excretion in 24 h collection（24 h Up） in chidren with renal disease. Methods A total of 162 children with renal disease in provided 24 h urine collections with concomitant spot urine specimens. The children were classified into four groups according to creatinine clearance （Ccr）. Correlation between 24 h Up and Up/Ucr was calculated. Results For children with Cer〈 10 mL/min, correlation between the 24 h Up and the Up/Ucr in spot urine specimens was not significant. For children with Ccr〉80 mL/min,50 - 80 mL/min, 10 - 50 mL/min, the correlation was highly significant, and coefficients were 0.86,0.93,0.74, respectively. Conclusion The Up/Ucr in spot urine samples can be used as an alternative to urine protein excretion in 24 h Up collections in children with Ccr〉10 mL/min.