尿α_1-微球蛋白与肺炎支原体感染致早期肾损害的相关性

Correlation between Urine α_1 - Microglobulin and Early Renal Injury Caused by Mycoplasma Pneumoniae

目的分析尿α1-微球蛋白与肺炎支原体(MP)感染致早期肾损害的相关性。方法检测24例血冷凝集试验阳性肺炎患儿的尿常规及尿微量蛋白,包括尿微量清蛋白(Alb)、尿α1-微球蛋白(α1-MG)、尿转铁蛋白(TF)和尿IgG。结果24例中仅1例尿蛋白呈阳性。尿α1-MG在血冷凝集试验<1:256与≥1:256两组及病程≤2周与>2周两组差异均具有显著性(P均<0.05),而其他3项尿微量蛋白组间比较均无显著性差异。结论MP感染致早期肾损害多表现为肾小管重吸收障碍,可能与免疫有关。尿α1-MG可用于MP感染致肾损害的早期诊断。

Objective Tc analyze the relation of urine α1 - microglobulin and early renal injury caused by mycoplasma pneurnoniae （MP）. Methods Twenty - four pneumonia children with positive cold agglutination test were enrolled, urine routine and urine microglobulins of them were investigated, the later including micro- albumin, α1 - microglobulin （α1 - MG）, transferrin （TF） and immunoglobulin G（IgG）. Results One patient＇s urine protein was positive, as to urine α1 - MG, significant differences existed both in cold agglutination test groups （titer less than 1：256 vs≥ 1：256）and course of disease groups（≤2 weeks vs 〉2 weeks） （both,P〈 0.05 ）, another three markers in such two groups had no differences. Conclusions Early renal injury caused by MP largely manifests as disturbance of tubular reabsorption, possibly due to immunization. Urine α1 - MG may be an early diagnostic maker in such condition.