血沉与肾癌肿瘤大小及分期的相关性分析

Analysis of correlation between erythrocyte sedimentation rate and tumor size/stage in renal cell carcinoma patients

目的分析肾细胞癌患者血沉增快程度和肿瘤大小及分期的相关性。方法2000年1月至2004年12月原发性肾透明细胞癌患者173例,均行根治性肾切除术并经病理证实。男120例,女53例。年龄37～86岁,平均61岁。肿瘤最大径≤2.5cm者30例,2.6～5.0cm者130例,>5.0cm者13例。临床分期T130例,T2125例,T317例,T41例。173例患者术前均行血沉检查。按血沉增快程度分4组,红细胞沉降率<25mm/h为轻度增快组(A组)、25mm/h～为中度增快组(B组),50mm/h～为高度增快组(C组)、>100mm/h为极度增快组(D组)。对4组肿瘤大小及分期进行差异性分析和相关性研究。结果血沉正常者89例,A组18例,B组49例,C组14例,D组3例。A～D4组肿瘤大小差异性分析显示,χ2=13.621,P=0.003;Spearman相关分析显示相关系数为0.341,P=0.002。A～D4组间肿瘤分期差异性分析显示,χ2=5.959,P=0.114;Spearman相关系数为0.208,P=0.057。结论血沉与肾细胞癌肿瘤大小呈正相关,与肿瘤分期间不存在相关性。

Objective To analyze the correlation between erythrocyte sedimentation rate （ESR） and tumor size/stage in renal cell carcinoma （RCC） patients. Methods From January 2000 to December 2004, 173 patients （ 120 men and 53 women ;mean age,61 years ; age range,37 - 86 years） with primary renal clear cell carcinoma underwent radical nephrectomy, and their diagnosis was pathologically confirmed. The greatest dimension of the tumors was ≤2.5 cm in 30 cases, 2.6-5.0 cm in 130 cases, 〉 5.0 cm in 13 cases. The clinical stage was T1 in 30 cases,T2 in 125 cases,T3 in 17 cases and T4 in 1 case. All the 173 cases underwent ESR test. They were divided into 4 groups according to their ESR results, ie, mildly rapid （ ≤25 mm/h,group A） , moderately rapid （ 〉25 to 50 mm/h,group B） ,highly rapid （ 〉50 to 100 mm/h, group C） and extremely rapid （ 〉 100 mm/h, group D）. The tumor size/stage of the 4 ESR groups were analyzed by means of SPSS10.0. Results There were 89 cases with normal ESR, 18 cases in group A,49 cases in group B, 14 cases in group C and 3 cases in group D. For the correlation of ESR and tumor size,the analysis resulted in X^2 = 13. 621, P = 0. 003;Spearman correlation analysis results were： correlation coefficient of 0. 341 ,P = 0. 002. For the correlation of ESR and tumor stage, the analysis resulted in X^2 = 5. 959 and P = 0. 114 ; Spearman correlation analysis results were ： correlation coefficient of 0. 208, P = 0. 057. Conclusions These results suggest that ESR is positively correlated with the size of renal cell carcinoma; however,there is no association between ESR and tumor stages.