期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

LPS诱导急性肺损伤大鼠肺组织甲状腺转录因子-1表达变化 被引量：3

Expression of TTF-1 in lung tissue of ALI rats induced by LPS
下载PDF
导出
摘要 目的探讨内毒素(LPS)诱导的急性肺损伤(ALI)大鼠肺组织甲状腺转录因子-1(TTF-1)、肺表面活性物质相关蛋白-A(SP-A)表达的变化。方法采用免疫组化和RT-PCR检测各组肺组织TTF-1、SP-A表达。结果ALI后12、24 h,肺组织中TTF-1、SP-A表达水平明显降低,且TTF-1蛋白变化与SP-A mRNA变化呈显著正相关。结论ALI大鼠肺组织TTF-1表达明显降低可能与ALI发生、发展有关。 Objective To investigate the change of the expression of TTF- 1 and SP - A in lung tissue of ALI rats induced by LPS. Methods The protein and mRNA of TTF- 1 and SP- A in lung tissue of ALI rats at different hours were measured with immunohistochemistry and RT- PCR method respectively, Results The expression of TTF- 1 and SP- A significantly decreased at 12 and 24 hours. A significant positive correlation between TTF- 1 and SP- A mRNA expression levels was detected, Conclusion The expression of TTF- 1 in lung tissue of ALI rats induced by LPS decreased, which may be related to the occurrence and development of ALI,
作者 李海东 游斌 刘国祥
机构地区 中国人民解放军第 中国人民解放军第三军医大学西南医院呼吸科
出处 《中国急救医学》 CAS CSCD 北大核心 2005年第11期810-812,共3页 Chinese Journal of Critical Care Medicine
关键词 急性肺损伤 内毒素 甲状腺转录因子-1 肺表面浩性物质相关蛋白-A Acute lung injury Lipopolysaccharide Thyroid transcription factor- 1 Surfactant protein A
分类号 R563 [医药卫生—呼吸系统]
  • 相关文献

参考文献6

  • 1Boggaram- V. Regulation of lung surfactant protein gene expression[J].Front Biosci, 2003, 8 (1): d751- 764.
  • 2Kumar VH, Ryan RM. Growth factors in the fetal and neonatal lung[ J].Front Biosci, 2004,1(9): 464-480.
  • 3DeFelice M,Silberschmidt D, DiLauro R, et al. TTF- 1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue- specific gene expression [ J ]. J Biol Chem, 2003, 278 (37): 35574 - 35 583.
  • 4Deepika Jain, Chandra Dodia, Sandra R, et al. SP- A is necessary for increased clearance of alveolar DPPC with hyperventilation or secretagogues [ J ]. Am J Physiol Lung Cell Mol Physiol, 2003,284 (15):759 - 765.
  • 5Matthias O, Georg J, Klaus - Michael M, et al. Intracellular and intraalveolar localization of surfactant protein A (SP- A ) in the parenchymal region of the human lung[J]. Am J Respir Cell Mol Biol,2002,26(1): 91-98.
  • 6Sophie C, Kamen K, Gérard L, et al. Inhibitory effects of surfactant protein a on surfactant phospholipid hydrolysis by secreted phospholipases A [J] .The Journal of Immunology, 2003, 171:995 - 1000.

同被引文献45

  • 1刘凯,李玖军,孙鹏,李倩影.骨髓间充质干细胞对急性肺损伤幼鼠炎症因子IL-1β、IL-10的影响[J].国际儿科学杂志,2018,45(12):973-977. 被引量：8
  • 2雷文章,韦靖江,沈文律,金立人.实验性坏死性胰腺炎多器官损害与内毒素血症的关系[J].中华实验外科杂志,1995,12(3):131-132. 被引量：117
  • 3李海东,王志成,刘国祥.氨溴索对内毒素诱导急性肺损伤大鼠肺组织表面活性物质相关蛋白A表达影响[J].西南军医,2006,8(1):32-34. 被引量：6
  • 4Zhu L.Endotoxin and acute respiratory distress syndrome.Zhang SC ed.Bass and clinic ofendotoxin.Beijing:Science Publishing House,2003:333-344.
  • 5Kuo C L, Chi C W,Jiu T Y,et al.The anti-intlannnatory po.tential of berberine in vitro and in vivofil.Cancer Lett,2004,203(2):127-137.
  • 6Chou T C,Chang L P,Li C Y,et al.The antiinflammatory and analgesic effects of baicalin in carragecnan-evoked thermal hyperaJ-gesia.AuesthA,mlg,2003,97(6): 1724-1729.
  • 7Barrett NA, Kam PC. Transfusion-related acute lung injury: literature review. Anesthesia,2006,61 ( 8 ) :777-785.
  • 8FDA Center for Biologics Evaluation and Research. Fatalities reported to FDA following blood collection and transfusion, annual summary for fiscal year 2008 [ Z/OL]. 2012-04-18 [ 2012-05-20 ] http://www, fda. gov/Biologics Blood Vaccines/SafetyAvailabili- ty/Reporta Problem/Transfusion Donation Fatalities/ucm113649. htm.
  • 9Urahama N, Tanosaki R, Masahiro K, et al. TRALI after the infusion of marrow cells in a patient with acute lymphoblastic leukemia. Transfusion,2003,43 ( 11 ) : 1553-1557.
  • 10Kleinmann S, Caulfield T, Chan P, et al. Towards an understanding of transfusion-related acute lung injury:statement of a consensus panel. Transfusion ,2004,44 ( 12 ) : 1774-1789.

引证文献3

二级引证文献36

中国急救医学
2005年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部