经肝动脉化疗栓塞联合无水酒精注射治疗原发性肝癌的疗效评价

Evaluation of the curative effect of transcatheter arterial chemoembolization via hepatic artery combined with percutaneous ethanol injection for the treatment of primary hepatocellular carcinoma

目的探讨肝动脉化疗栓塞术联合无水酒精注射治疗原发性肝癌的疗效。方法61例不能手术切除的中晚期肝癌和拒绝手术的早期肝癌患者随机分为A,B两组。A组:经导管肝动脉化疗栓塞组(TACE组),共34例;B组:肝动脉化疗栓塞联合无水酒精注射治疗组(联合治疗组),共27例。结果TACE组的完全坏死率、肿瘤缩小率及1年死亡率分别为26.5%,61.8%和35.3%;而联合治疗组分别为92.6%,92.6%和3.7%。两组间完全坏死率、肿瘤缩小率及1年死亡率的差异皆有显著性意义(其相应P值分别为0.000,0.005,0.004)。结论肝动脉化疗栓塞联合无水酒精注射治疗效果明显优于单纯化疗栓塞。

Objective To investigate the curative effect of transcatheter arterial chemoembolization （TACE） combined with percutaneous ethanol injection （PEI） for the treatmem of primary hepatocellular carcinoma. Methods Sixty-one cases with primary hepatecellular carcinoma were divided into group A and group B. In group A, 34 cases were iterated with TACE, and 27 cases were treated with TACE and PEI in gmup B.Results Thecomplete necrosis of tumor, the reduction rate of tumor, and one-year death rate were 26.5%, 61.8% and 35.3%, respectively in group A, and 92.6%, 92.6% and 3.7%, rspectively in group B. There were significant statistical differences between the two groups （P value were 0.000, 0. 005 and 0. 004, respectively）. Conclusion The curative effect of TACE combined with PEI shows better results than that of TACE alone.