α-干扰素联合护肝宁片治疗慢性乙型肝炎疗效观察

Treatment of chronic hepatitis B patients with interferon in combination with Huganning.

目的观察注射用重组人干扰素α-2b联合护肝宁片治疗慢性乙型肝炎临床疗效。方法将HBsAg、HBeAg和HBV-DNA同时阳性的62例慢性乙肝患者分为α-2b干扰素加护肝宁片的联合治疗组及单用α-2b干扰素的对照组,两组对比治疗,联合组34例,对照组28例,干扰素均为每周3次,每次5×106u,肌肉注射,半年为一疗程,护肝宁片每日3次,每次4粒,3个月,治疗结果进行总结。结果联合组总有效率91.2%,对照组为71.4%,统计学处理(P<0.05)有显著差异存在。联合组HBeAg和HBV-DNA转阴率分别为60.7%和60%,优于对照组。结论联合组慢性乙型肝炎不良反应少,疗效优于单一用药组。

Objectlve To observe the therapeutic effect of α-interferon in combination with Huganning tablet on chronic hepatitis B patients. Methods Sixty - two chronic hepatitis B patients with positive HBsAg, HBeAg and HBV - DNA were divided into observation group consisted of 34 patients treated with α-nterferon in combination with Huganning tablet and control group treated with α-interferon. The α-nterferon was intramuscularly given with the dose of 5 × 10^6u, three times/day for course of 6 months and Hugannlng was orally given with the dose of 4 gains X3 times/day for a duration of 3 months. The results were analyzed after completion the experiment. Results The total effective rate in the observation group was 91.2% and 71.4% in the control group, showing a significant difference between the two groups （P 〈 0.05）, The negative conversion rates for HBeAg and HBV- DNA in the observation groups were 60,7% and 60,0% superior to the control group. Conclusion The therapeutic effect in the observation group is superior to the control group with less adversary effect.