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Effects of the Chinese Herbal Medicine Based on Hachimi-jio-gan in Male Rats with the Adenine-Induced Osteopenia 被引量:1

Effects of the Chinese Herbal Medicine Based on Hachimi-jio-gan in Male Rats with the Adenine-Induced Osteopenia
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摘要 In the adenine-induced renal failure rats, reversibility of renal failure and recovery of bone mineral density (BMD) by discontinuation of adenine-rich diet were reported: We think that the effect to bone metabolism with medication may be able to be evaluated as reinforcement of the BMD recovery. We have so far investigated the Chinese herbal medicine based on Hachimi-jio-gan (HJG) which are more effective than HJG alone. In this study, we investigated the effects of our Chinese herbal prescription on BMD in the adenine-treated rats compared to that of vitamin D3treatment. Young male rats were administrated 100 mg/ml adenine for 8 weeks, and they showed renal failure and bone loss. The adenine-treated rats were divided into the following 3 groups, that is, the group experienced no treatment (control), the group givenour Chinese herbal medicine (HAO), and the group given vitamin D3 (VD3) medication. It is likely that VD3 medication was less effective for increase of the femoral BMD than increase of the spinal BMD. In contrast, HAO was effective for increase of the femoral BMD. The VD3 group showed low deoxypyridinoline (Dpd: bone resorption maker) as compared to the control group.However, the HAO group showed same or slightly high Dpd. It is suggested that VD3 may increase BMD by reduction of bone resorption, while HAO may show effect on BMD by activating bone metabolism. It is indicated that HAO may become a curative medicine for bone loss because of the different target site from vitamin D3. In the adenine-induced renal failure rats, reversibility of renal failure and recovery of bone mineral density (BMD) by discontinuation of adenine-rich diet were reported. We think that the effect to bone metabolism with medication may be able to be evaluated as reinforcement of the BMD recovery. We have so far investigated the Chinese herbal medicine based on Hachirni-jio-gan (HJG) which are more effective than HJG alone. In tiffs study, we invesdgated the effects of our Chinese herbal presctiption on BMD in the adenine-treated rats compared to that of vitamin D3 treatment. Young male rats were adminisWated 100 mg/ml adenine for 8 weeks, and they showed renal failure and bone loss. The adenine-treated rats were divided into the following 3 groups, that is, the group experienced no treatment (control), the group given our Chinese hemal medicine (HAO), and the group given vitamin 193 (VD3) medication. It is likely that VD3 medication was less effective for increase of the femoral BMD than increase of the spinal BMD. In contrast, HAO was effective for increase of the femtxal BMD. The VD3 group showed low deoxypyridinoline (Dpd: bone resorption maker) as compared to the control group. However, the HAO group showed same or slightly high DIXL It is suggested that VD3 may increase BMD by reduction of bone resorption, while HAO may show effect on BMD by activating bone metabolism. It is indicated that HAO may become a curative medicine for bone loss because of the different target site from vitamin D3.
出处 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2005年第3期226-232,共7页 中医杂志(英文版)
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  • 1T.S. Kaastad,O. Reiker?s,V. Halvorsen,J.A. Falch,K.J. Obrant,L. Nordsletten.Vitamin D Deficiency and Ovariectomy Reduced the Strength of the Femoral Neck in Rats[J].Calcified Tissue International.2001(2)
  • 2H. Okada,Yoshiteru Kaneko,Takiko Yawata,Hideto Uyama,Seiichiro Ozono,Yoshihiro Motomiya,Yoshihiko Hirao.Reversibility of adenine-induced renal failure in rats[J].Clinical and Experimental Nephrology.1999(2)
  • 3S. Hidaka,Y. Okamoto,K. Nakajima,M. Suekawa,S. Y. Liu.Preventive Effects of Traditional Chinese (Kampo) Medicines on Experimental Osteoporosis Induced by Ovariectomy in Rats[J].Calcified Tissue International.1997(3)
  • 4P. Geusens,J. Dequeker,J. Nijs,A. Verstraeten,E. Bramm.Prevention and treatment of osteopenia in the ovariectomized rat: Effect of combined therapy with estrogens, 1-alpha vitamin D, and prednisolone[J].Calcified Tissue International.1991(2)

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