p16^(INK4A)蛋白在宫颈癌及其癌前病变诊断中的意义

The significance of p 16^(INK4A) in the diagnosis of cervical malignant neoplasm and it's precursors

[目的]探讨P 16INK4A蛋白的过度表达在宫颈癌及其癌前病变早期诊断中的病理学意义[方法]采用免疫组织化学方法检测47例宫颈浸润型鳞状上皮癌、30例宫颈上皮内新生物(CIN)、20例宫颈浸润型腺癌和20例非肿瘤性宫颈病变(慢性宫颈炎)标本中P 16INK4A蛋白的表达[结果]p 16INK4A 蛋白过度表达在100%的宫颈浸润型腺癌,79%的宫颈浸润型鳞状上皮癌和97%的CIN病变标本中出现.[结论]P 16INK4A蛋白的过度表达可作为早期诊断宫颈癌及其癌前病变的指标,

OBJECTIVE To evaluate the early diagnostic value of p 16^INK4A in cervical malignant neoplasm and it＇s precursors. METHODS The immunohistochemistry method was used to determine the impress of p 16^INK4A monoclonal antibody in 47 of invasive squamous cell carcinomas, 30 of cervical intraepithelial neoplasia（CIN）, 20 of adenocarcinomas, and 20 of non-neoplastic cervices. RESULTS p 16^INK4A was specifically detected in 100 % of adenocarcinomas, 79 % of squamous cell carcinoma, and 97 % of CIN. CONCLUSION p 16^INK4A overexpression was a useful marker for the early diagnosis of epithelial neoplasm and it＇s precursors of cervix uteri.