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尾加压素Ⅱ与心血管疾病的研究进展

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摘要 尾加压素Ⅱ(urotensinⅡ,UⅡ)最早是从鱼尾下垂体中提取出的神经肽,近年来陆续发现多种哺乳动物,如人、大鼠、小鼠及猪的体内均含有UⅡ,在神经系统中含量较丰富[1～4].1999年Ameg等[1]首先发现了人体内孤立的G蛋白偶联受体(GPR)14为UⅡ特异性受体,主要存在于心血管系统,且成功克隆出人尾加压素-Ⅱ(human urotensinⅡ,hUⅡ).UⅡ和受体结合后可引起钙离子内流,发挥收缩血管物质的生物学效应.UⅡ是迄今为止发现的最强的血管收缩肽,提示它可能在心血管疾病的发生和发展中起重要的作用.
作者 吴美善 金海
机构地区 延边大学医院心内科
出处 《延边大学医学学报》 CAS 2005年第3期220-223,共4页 Journal of Medical Science Yanbian University
关键词 心血管疾病 尾加压素 缩血管肽
分类号 R331.3 [医药卫生—人体生理学]
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参考文献13

  • 1Ames RS, Sarau HM, Chanbers JK, et al. Human urotensin Ⅱ is a potent vasoconstrictor and agonist for the orphan receptor GPR 14[J]. Nature, 1999,16:282.
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二级参考文献30

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共引文献14

延边大学医学学报
2005年 第3期

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