人体海马及杏仁核体积的MRI测定

Volumetric Measurement of Hippocampus and Amygdala Based on MRI

目的应用高分辨率磁共振(MRI)和三维体积分析软件(Surgiplan)测定人体海马及杏仁核的体积。方法选择健康成年日本人30名(男∶女=16∶14)作为研究对象。用TOSHIBA3.0T磁共振机对所有对象行MRI检查,层厚0.5mm,分别行T1、T2和质子加权的矢状、水平和冠状位扫描,在动态三维图象上勾画出海马、杏仁核轮廓图,输入Surgiplan工作站,用三维体积分析软件进行半自动分割分析,得出体积。结果海马平均体积:右侧(2895.0±300.2)mm3[男(3033.3±334.3)mm3,女(2687.5±298.4)mm3],左侧(2630.0±320.7)mm3[男(2683.3±323.5)mm3,女(2550.0±269.7)mm3]。杏仁核平均体积:右侧(791.1±170.2)mm3[男(852.0±210.5)mm3,女(696.5±181.3)mm3],左侧(794.2±140.6)mm3[男(868.2±187.0)mm3,女(683.1±133.4)mm3]。结论应用高分辨率磁共振分割分析技术和三维体积分析软件(Surgiplan)可以动态三维确认人体海马、杏仁核轮廓,进而准确测定其体积。

Objective To measure both the hippocampal volume and amygdaloid volume in normal subjects by. high-resolution MRI and three-dimensional software Surgiplan. Methods This study was performed in 30 normal subjects （male, 16 and female, 14）. This protocol generates T1, T2 and PD-weighted image volumes with a slice separation of 0.5 mm. Data acquisition was performed with a three-dimensional gradient echo technique, and the scans were corrected for non-uniformity and registered into standard stereotaxic space prior to segmentation. Volumetric analysis was performed by three-dimensional software that allows simultaneous analysis of sagittal, coronal and horizontal images. Results The mean volumes of right and left hippocampus were （2895.0±300.2）mm^3 [male, （3033.3±334.3）mm^3 and female, （2687.5±298.4）mm^3] and （2630.0±32.07）mm^3 [male, （2683.3±323.5）mm^3 and female, （2550.0-269.7） mm^3] respectively. The mean volumes of right and left amygdala were （791.1±170.2）mm^3 [male, （852.0±210.5）mm^3 and female （696.5±181.3）mm^3], （794.2±140.6）mm^3 [male, （868.2±187.0）mm^3 and female, （683.1±133.4）mm^3] respectively. Conclusion The high-resolution MRI and the three-dimensional analysis software （Surgiplan） allowed simultaneous employment of coronal, transverse and sagittal images for visualization and segmentation, and the irregularly shaped hippocampus and amygdala can be reliably and precisely segmented and volumetrically analyzed.