惊恐障碍血脂、血糖与脑血流研究

Study on plasma lipid, blood sugar, Cerebral Blood Flow in panic disorder patients

目的研究惊恐障碍(PD)血脂、血糖与脑血流的改变及其相关因素。方法30例PD为研究组,GAD30例及GAD合并PD30例、正常人22例为三组对照组(GAD组、GAD+PD组、NC组)。所有样本均检测血脂(TG、TC、HDL、LDL)、血糖(GLU)及脑血流量。比较PD组与GAD+PD组、GAD组、NC组间的差别,并对PD组有关指标作多元逐步回归分析。结果TC浓度PD组较NC组高;TC浓度与HDL及年龄正相关。脑血流测定,PD组左侧大脑中动脉收缩峰、右侧大脑中动脉收缩峰及右侧大脑中动脉平均峰较NC组低(P<0.05),右侧椎动脉收缩峰较GAD组及NC组低。左侧大脑中动脉收缩峰除受其它大脑动脉影响外与TC呈正相关,年龄及女性呈负相关;右侧大脑中动脉平均峰除受其它大脑动脉影响外与年龄呈负相关。右侧椎动脉收缩峰除受其它大脑动脉影响外与女性呈正相关,与TC、LDL呈负相关。结论PD患者存在着血脂及脑血流方面的改变。

Objective To explore the changes of plasma lipid, blood sugar, cerebral blood flow and correlation factors in panic disorder patients. Methods Plasma lipid, blood sugar and Cerebral blood flow in 112 patients including 30 cases of PD, 30 cases of GAD, 30 cases of GAD plus PD and 22 normal cases were measured. Compared the difference of factors between groups. Correlation factors were analyzed by regression analyzed in PD groups. Results The concentration of TC was higher in PD group than in NC group, which was positive correlation with HDL and age. Cerebral blood flow was significant difference between four groups, which was correlation with age, sexuality, TC, LDL. Conclusion There are changes of plasma lipid and Cerebral Blood Flow in panic disorder patients.