TE方案与CE方案治疗复发性小细胞肺癌的对比研究

Comparative study of the treatment effects of TE and CE regimen on recurrent small-cell lung cancer

目的观察紫杉醇(Taxol)联合足叶乙甙(VP-16)与卡铂(CBP)联合足叶乙甙治疗复发性小细胞肺癌(SCLC)的有效性和安全性。方法将44例SCLC分为两组,A组20例,用TE方案(Taxol+VP-16),B组24例,用CE方案(CBP+VP-16)。两组的治疗周期均为28天,完成2个周期后评价疗效及毒副作用。结果TE方案有效率60%(12/20),CE组有效率25%(6/24),两组疗效有显著差异(P<0.05),两组毒副作用主要表现为骨髓抑制,恶心、呕吐和脱发,TE组有肌肉关节痛。结论TE方案治疗复发性SCLC的疗效高于CE方案。

Objective：To evaluate and compare the effects of TE（Taxol ＋ VP-16） regimen and CE（CBP ＋ VP-16） regimen for recurrent small-cell lung cancer （SCLC）. Methods：The 44 patients of recurrent SCLC were divided into 2 groups. The group A which was treated with TE regimen was enrolled 20 cases and the group B which was treated with CE regimen was enrolled 24 cases. Results：The results showed that the response rates of group A and group B were 60% （12/20） and 25% （6/24%）, respectively. There was significant difference between them（ P 〈 0. 05 ）. The main toxicity and side-effects were myelosuppression, nausea, vomiting and alopecia. Conclusion：The efficacy of TE regimen was better than CE regimen in recurrent SCLC.