造血调控相关的细胞因子与血管内皮祖细胞

Vascular Endothelial Progenitor Cells and Cytokines Related to Hematopoietic Regulation——Review

血管内皮祖细胞是一类能循环、增殖并能直接分化为血管内皮细胞的前体细胞。研究血管内皮祖细胞对于了解成人生理性和病理性血管形成的过程有重要意义,而细胞因子尤其是造血调控相关的细胞因子作为体内的细胞刺激物质对血管内皮祖细胞也有重要作用。本文将对血管内皮祖细胞和一些造血调控相关的细胞因子(GCSF、EPO、HAPO和IL18)的关系及其可能的信号传导途径的研究进展作一综述。

Endothelial progenitor cell （EPC） is a subtype of progenitor cells that can circulate, proliferate and have the ability to differentiate into mature endothelial cells. Exploration of EPC have significance to understand the vascular forming process of adults physiologically and pathologically. Cytokines, especially haematopiesis-related cytokines, cellular stimulating factors in the body also influence EPC. In this review, the advances of research on the relationship between EPC and some cytokines related with haematopoiesis （G-CSF,EPO,HAPO and IL-18 ）and the potential signal transduction pathway were summarised.