慢性肺心病血浆D-二聚体等指标水平测定的临床意义

Clinical study on the detection of plasma levels of D-dimmer and coagulation factors VIII in patients with pulmonary heart disease

目的观察慢性肺心病急性发作期患者治疗前后血浆D-二聚体、VIII:Ag和VIII:C水平的变化,探讨其在疗效观察及预后判断的价值。方法采用ELISA等方法测定肺心病患者治疗前后血浆D-二聚体、VIII:Ag和VIII:C等水平。结果肺心病急性发作期血浆D-二聚体、VIII:Ag和VIII:C水平与正常人相比明显增高(P<0.01)。治疗好转后三项指标均明显下降,与急性发作期相比差异有显著性(P<0.01)。结论检测肺心病病人的D-二聚体等指标对判定体内高凝状态及有无肺小动脉血栓形成等有重要意义,且检测方法简便,可作为判定肺心病病人病情严重程度、疗效观察及判断预后的指标之一。

Objective To study the clinic significance of changes of plasma levels of D - dimer, coagulation factor Ⅷ in patients with acute exacerbation of chronic pulmonary heart disease. Methods Enzyme Linked Immune Sorbent Assay（EIISA） was used to detect the plasma levels of D - dimer, coagulation factor ⅧR ： Ag and Ⅷ ： C in patients with acute exacerbation of chronic pulmonary heart disease before and after treatment. Results The plasma levels of D- dimmer, ⅧR：Ag and Ⅷ：C in patients with acute exacerbation of chronic pulmonary heart disease were significantly higher than that of control group （P 〈 0.01 ）. After treatment, the plasma levels of D- dimmer, ⅧR：Ag and Ⅷ：C were significantly decreased （P 〈 0.01）. Conclusion D- dimer in plasma can be used as an index of the thrombus in small pulmonary artery of chronic pulmonary heart disease.