肺癌咯血50例治疗效果观察

Observation on the effect of treatment with internal medicine on 50 hemoptysis lung cancer patients

目的比较应用普鲁卡因和垂体后叶素治疗肺癌咯血的疗效和安全性。方法将50例肺癌咯血病人随机分为垂体后叶素治疗组24例和普鲁卡因组26例,观察两组的止血效果。结果临床有效率:垂体组和普鲁卡因组分别为71%和92%,两组比较差异有显著性(P<0.05);止血时间比较:垂体组(6.3±3.1)h,普鲁卡因组(5.3±2.2)h,两组比较差异有显著性(P<0.05);副作用发生率:垂体组和普鲁卡因组分别为38%和15%,两组比较差异无显著性(P>0.05)。结论应用普鲁卡因治疗肺癌咯血效果优于应用垂体后叶素治疗,值得推广。

Objective To compare the clinical effect and safety between to apply pituitrine and procaine on treatment of hemoptysis caused by ling cancer. Methods 50cases of hemoptsis caused by lung cancer were randomly divided into two groups . Pituitrine group 24 cases, procaine group 16 cases. Under routine treatment, group Ⅰ （pituitrne）24 cases ware given 5 % GS 500ml ＋ pituitrin 20 - 40u. cir. The flowing speed was controlled 1 - 2u/h . Group Ⅱ （procaine） 26 cases were given 5 % GS 500ml ＋ procaine 0.3 - 0.Sg . cir. Flowing speed was controlled 20 - 30gtt. min. Results The curative rate in procaine group was higher than in pituitrin, the difference was statistically significant （92% vs 71%, P 〈 0.05）, the time for hemostasis in procaine group was significantly shorter than that in pituitrin group, the difference was statistically significant （5.3 ± 2.2）h vs （6.3 ± 3.1）h, P 〈 0.05. The side - effect rate in procaine group was less than in pituitrine group , the difference was not statistically significant （ 15 % vs 38%, P 〉 0.05）. Conclusion Procaine is superior to pituitrin on treantment of hemoptysis caused by lung cancer, which is worth applying extensively.